{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":56,"searchCount":0},"additional":{"submitter":["de las Fuentes L"],"funding":["NCATS NIH HHS","NCRR NIH HHS","NHLBI NIH HHS"],"pagination":["954-60"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2536614"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(8)"],"pubmed_abstract":["<h4>Background</h4>Osteopontin (OPN)-transgenic mice exhibit increased carotid artery intima-media thickness (CIMT), smooth muscle cell proliferation, and atheroma formation.<h4>Methods</h4>An association of the human T-66G promoter variant with CIMT was examined in Caucasian adults grouped according to metabolic syndrome criteria: present (+MetS; n = 70) or absent (-MetS; n = 70).<h4>Results</h4>The G-allele frequency was 22%. For the entire cohort, the G group (TG and GG) was associated with significantly lower age-adjusted and gender-adjusted CIMT compared with the TT group (P = .008); similar analysis by metabolic syndrome group found a significant difference only in the -MetS group (P = .018). Stepwise multivariate regression showed that after age and waist circumference, the T-66G variant was the next most predictive of CIMT (P = .007). These data suggest that in a normoglycemic environment, human vascular OPN gene expression contributes to arterial structure, an effect diminished in dysmetabolic states.<h4>Conclusion</h4>Humans with the OPN -66 TT genotype, particularly those without metabolic syndrome, exhibit thicker CIMT."],"journal":["Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography"],"pubmed_title":["Osteopontin promoter polymorphism is associated with increased carotid intima-media thickness."],"pmcid":["PMC2536614"],"funding_grant_id":["K12 RR023249","R01 HL071782-02","M01 RR000036-441464","KL2 RR024994","R01 HL071782-03","R01 HL071782-04","R01 HL058878","R01 HL081138","R01HL81138","KL2 RR024994-02","K24 HL067002-01A1","M01 RR000036","KL2 RR024994-01","K12RR023249","TL1 TR000449","K24 HL067002-05","K24 HL067002-03","K24 HL067002-04","R01HL71782","K24 HL067002-02","UL1 TR000448","R01 HL069229-05","R01 HL069229-04","R01 HL069229-03","P50 HL083762","R01 HL069229-02","R01HL58878","R01 HL069229-08","R01 HL069229-07","R01 HL069229-06","U01 HL054473","R01 HL069229-01","L30 HL074749","K24 HL067002","R01 HL071782","K24HL67002","L30 HL074749-03","TL1 RR024995","P50 HL083762-01","P50 HL083762-03","P50 HL083762-02","R01 HL071782-01A1","R01 HL069229","KL2RR024994","R01HL69229","M01RR00036","KL2 TR000450","HL54473","P50HL83762","TL1 RR024995-01","U10 HL054473","TL1 RR024995-02"],"pubmed_authors":["de las Fuentes L","Reagan JL","Waggoner AD","Lai CF","Ruthmann NP","Towler DA","Davila-Roman VG","Gu CC","Mathews SJ"],"view_count":["56"],"additional_accession":[]},"is_claimable":false,"name":"Osteopontin promoter polymorphism is associated with increased carotid intima-media thickness.","description":"<h4>Background</h4>Osteopontin (OPN)-transgenic mice exhibit increased carotid artery intima-media thickness (CIMT), smooth muscle cell proliferation, and atheroma formation.<h4>Methods</h4>An association of the human T-66G promoter variant with CIMT was examined in Caucasian adults grouped according to metabolic syndrome criteria: present (+MetS; n = 70) or absent (-MetS; n = 70).<h4>Results</h4>The G-allele frequency was 22%. For the entire cohort, the G group (TG and GG) was associated with significantly lower age-adjusted and gender-adjusted CIMT compared with the TT group (P = .008); similar analysis by metabolic syndrome group found a significant difference only in the -MetS group (P = .018). Stepwise multivariate regression showed that after age and waist circumference, the T-66G variant was the next most predictive of CIMT (P = .007). These data suggest that in a normoglycemic environment, human vascular OPN gene expression contributes to arterial structure, an effect diminished in dysmetabolic states.<h4>Conclusion</h4>Humans with the OPN -66 TT genotype, particularly those without metabolic syndrome, exhibit thicker CIMT.","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Aug","modification":"2024-11-06T17:39:20.673Z","creation":"2019-06-06T19:32:20Z"},"accession":"S-EPMC2536614","cross_references":{"pubmed":["18406574"],"doi":["10.1016/j.echo.2008.02.005"]}}