{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Jiang WG"],"pubmed_abstract":["<h4>Introduction</h4>To investigate the expression of EPLIN-alpha, epithelial protein lost in neoplasm, in human breast cancer tissues/cells and investigate the cellular impact of EPLIN-alpha on breast cancer cells.<h4>Experimental design</h4>EPLIN-alpha was determined in tumour (n = 120) and normal mammary tissues (n = 32), and cancer cell lines (n = 16). Cell invasion, in vitro and in vivo growth of cells transfected with EPLIN-alpha were evaluated using in vitro invasion assay, in vitro and in vivo tumour model. Cellular migration was analysed using Electric Cell Impedance Sensing assays.<h4>Results</h4>Low level of EPLIN-alpha was seen in tumour tissues. Grade-2/3 tumours had significantly lower levels of EPLIN-alpha compared with grade-1 (p = 0.047 and p = 0.046 vs grade-1, respective"],"journal":["Molecular cancer"],"pagination":["71"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2553413"],"repository":["biostudies-literature"],"pubmed_title":["Eplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcome."],"pmcid":["PMC2553413"],"pubmed_authors":["Mansel RE","Ye L","Lewis-Russell JM","Martin TA","Douglas-Jones A","Jiang WG"],"additional_accession":[]},"is_claimable":false,"name":"Eplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcome.","description":"<h4>Introduction</h4>To investigate the expression of EPLIN-alpha, epithelial protein lost in neoplasm, in human breast cancer tissues/cells and investigate the cellular impact of EPLIN-alpha on breast cancer cells.<h4>Experimental design</h4>EPLIN-alpha was determined in tumour (n = 120) and normal mammary tissues (n = 32), and cancer cell lines (n = 16). Cell invasion, in vitro and in vivo growth of cells transfected with EPLIN-alpha were evaluated using in vitro invasion assay, in vitro and in vivo tumour model. Cellular migration was analysed using Electric Cell Impedance Sensing assays.<h4>Results</h4>Low level of EPLIN-alpha was seen in tumour tissues. Grade-2/3 tumours had significantly lower levels of EPLIN-alpha compared with grade-1 (p = 0.047 and p = 0.046 vs grade-1, respective","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Sep","modification":"2025-04-05T12:16:02.195Z","creation":"2019-06-06T19:49:57Z"},"accession":"S-EPMC2553413","cross_references":{"pubmed":["18796137"],"doi":["10.1186/1476-4598-7-71"]}}