biostudies-literatureUnknown7Jiang WG<h4>Introduction</h4>To investigate the expression of EPLIN-alpha, epithelial protein lost in neoplasm, in human breast cancer tissues/cells and investigate the cellular impact of EPLIN-alpha on breast cancer cells.<h4>Experimental design</h4>EPLIN-alpha was determined in tumour (n = 120) and normal mammary tissues (n = 32), and cancer cell lines (n = 16). Cell invasion, in vitro and in vivo growth of cells transfected with EPLIN-alpha were evaluated using in vitro invasion assay, in vitro and in vivo tumour model. Cellular migration was analysed using Electric Cell Impedance Sensing assays.<h4>Results</h4>Low level of EPLIN-alpha was seen in tumour tissues. Grade-2/3 tumours had significantly lower levels of EPLIN-alpha compared with grade-1 (p = 0.047 and p = 0.046 vs grade-1, respectiveMolecular cancer71https://www.ebi.ac.uk/biostudies/studies/S-EPMC2553413biostudies-literatureEplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcome.PMC2553413Mansel REYe LLewis-Russell JMMartin TADouglas-Jones AJiang WGfalseEplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcome.<h4>Introduction</h4>To investigate the expression of EPLIN-alpha, epithelial protein lost in neoplasm, in human breast cancer tissues/cells and investigate the cellular impact of EPLIN-alpha on breast cancer cells.<h4>Experimental design</h4>EPLIN-alpha was determined in tumour (n = 120) and normal mammary tissues (n = 32), and cancer cell lines (n = 16). Cell invasion, in vitro and in vivo growth of cells transfected with EPLIN-alpha were evaluated using in vitro invasion assay, in vitro and in vivo tumour model. Cellular migration was analysed using Electric Cell Impedance Sensing assays.<h4>Results</h4>Low level of EPLIN-alpha was seen in tumour tissues. Grade-2/3 tumours had significantly lower levels of EPLIN-alpha compared with grade-1 (p = 0.047 and p = 0.046 vs grade-1, respective2008-01-01T00:00:00Z2008 Sep2025-04-05T12:16:02.195Z2019-06-06T19:49:57ZS-EPMC25534131879613710.1186/1476-4598-7-71