{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Foy RL"],"funding":["NIDDK NIH HHS","NIEHS NIH HHS","NCI NIH HHS","CIHR"],"pagination":["28817-26"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2570895"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["283(43)"],"pubmed_abstract":["Regulation of global chromatin acetylation is important for chromatin remodeling. A small family of Jade proteins includes Jade-1L, Jade-2, and Jade-3, each bearing two mid-molecule tandem plant homology domain (PHD) zinc fingers. We previously demonstrated that the short isoform of Jade-1L protein, Jade-1, is associated with endogenous histone acetyltransferase (HAT) activity. It has been found that Jade-1L/2/3 proteins co-purify with a novel HAT complex, consisting of HBO1, ING4/5, and Eaf6. We investigated a role for Jade-1/1L in the HBO1 complex. When overexpressed individually, neither Jade-1/1L nor HBO1 affected histone acetylation. However, co-expression of Jade-1/1L and HBO1 increased acetylation of the bulk of endogenous histone H4 in epithelial cells in a synergistic manner, sugg"],"journal":["The Journal of biological chemistry"],"pubmed_title":["Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex."],"pmcid":["PMC2570895"],"funding_grant_id":["R01 DK087910","K08 DK080946","87253-1","R01 DK67569","R01 DK067569","R01 CA79830","R01 ES12917","64289-2","R01 CA079830"],"pubmed_authors":["Saksouk N","Cayrou C","Cote J","Panchenko MV","Song IY","Vaziri C","Cohen HT","Foy RL","Chitalia VC"],"additional_accession":[]},"is_claimable":false,"name":"Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex.","description":"Regulation of global chromatin acetylation is important for chromatin remodeling. A small family of Jade proteins includes Jade-1L, Jade-2, and Jade-3, each bearing two mid-molecule tandem plant homology domain (PHD) zinc fingers. We previously demonstrated that the short isoform of Jade-1L protein, Jade-1, is associated with endogenous histone acetyltransferase (HAT) activity. It has been found that Jade-1L/2/3 proteins co-purify with a novel HAT complex, consisting of HBO1, ING4/5, and Eaf6. We investigated a role for Jade-1/1L in the HBO1 complex. When overexpressed individually, neither Jade-1/1L nor HBO1 affected histone acetylation. However, co-expression of Jade-1/1L and HBO1 increased acetylation of the bulk of endogenous histone H4 in epithelial cells in a synergistic manner, sugg","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Oct","modification":"2025-04-22T06:45:28.374Z","creation":"2019-03-27T00:19:00Z"},"accession":"S-EPMC2570895","cross_references":{"pubmed":["18684714"],"doi":["10.1074/jbc.M801407200","10.1074/jbc.m801407200"]}}