{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lu P"],"funding":["NICHD NIH HHS","NIEHS NIH HHS","NHLBI NIH HHS","NCI NIH HHS"],"pagination":["77-87"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2582391"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["321(1)"],"pubmed_abstract":["FGF signaling is associated with breast cancer and is required for mammary placode formation in the mouse. In this study, we employed a genetic mosaic analysis based on Cre-mediated recombination to investigate FGF receptor 2 (Fgfr2) function in the postnatal mammary gland. Mosaic inactivation of Fgfr2 by the MMTV-Cre transgene enabled us to compare the behavior of Fgfr2 null and Fgfr2 heterozygous cells in the same gland. Fgfr2 null cells were at a competitive disadvantage to their Fgfr2 heterozygous neighbors in the highly proliferative terminal end buds (TEBs) at the invasion front, owing to a negative effect of loss of Fgfr2 function on cell proliferation. However, Fgfr2 null cells were tolerated in mature ducts. In these genetic mosaic mammary glands, the epithelial network is apparen"],"journal":["Developmental biology"],"pubmed_title":["Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis."],"pmcid":["PMC2582391"],"funding_grant_id":["CA057621","U01 ES012801","HD025331","HL07731","R01 CA057621","R37 HD025331-20","T32 HL007731-09","T32 HL007731","R01 CA057621-14","R37 HD025331","ES012801","U01 ES012801-05"],"pubmed_authors":["Werb Z","Martin GR","Lu P","Ewald AJ"],"additional_accession":[]},"is_claimable":false,"name":"Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis.","description":"FGF signaling is associated with breast cancer and is required for mammary placode formation in the mouse. In this study, we employed a genetic mosaic analysis based on Cre-mediated recombination to investigate FGF receptor 2 (Fgfr2) function in the postnatal mammary gland. Mosaic inactivation of Fgfr2 by the MMTV-Cre transgene enabled us to compare the behavior of Fgfr2 null and Fgfr2 heterozygous cells in the same gland. Fgfr2 null cells were at a competitive disadvantage to their Fgfr2 heterozygous neighbors in the highly proliferative terminal end buds (TEBs) at the invasion front, owing to a negative effect of loss of Fgfr2 function on cell proliferation. However, Fgfr2 null cells were tolerated in mature ducts. In these genetic mosaic mammary glands, the epithelial network is apparen","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Sep","modification":"2025-04-20T02:07:43.355Z","creation":"2019-03-27T00:19:20Z"},"accession":"S-EPMC2582391","cross_references":{"pubmed":["18585375"],"doi":["10.1016/j.ydbio.2008.06.005"]}}