{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["205(12)"],"submitter":["Nottebaum AF"],"pubmed_abstract":["We have shown recently that vascular endothelial protein tyrosine phosphatase (VE-PTP), an endothelial-specific membrane protein, associates with vascular endothelial (VE)-cadherin and enhances VE-cadherin function in transfected cells (Nawroth, R., G. Poell, A. Ranft, U. Samulowitz, G. Fachinger, M. Golding, D.T. Shima, U. Deutsch, and D. Vestweber. 2002. EMBO J. 21:4885-4895). We show that VE-PTP is indeed required for endothelial cell contact integrity, because down-regulation of its expression enhanced endothelial cell permeability, augmented leukocyte transmigration, and inhibited VE-cadherin-mediated adhesion. Binding of neutrophils as well as lymphocytes to endothelial cells triggered rapid (5 min) dissociation of VE-PTP from VE-cadherin. This dissociation was only seen with tumor n"],"journal":["The Journal of experimental medicine"],"pagination":["2929-45"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2585844"],"repository":["biostudies-literature"],"pubmed_title":["VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF."],"pmcid":["PMC2585844"],"pubmed_authors":["Bixel MG","Cagna G","Filippova K","Butz S","Lyck R","Winderlich M","Vestweber D","Engelhardt B","Gamp AC","Polaschegg C","Kamenyeva O","Linnepe R","Nottebaum AF"],"additional_accession":[]},"is_claimable":false,"name":"VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF.","description":"We have shown recently that vascular endothelial protein tyrosine phosphatase (VE-PTP), an endothelial-specific membrane protein, associates with vascular endothelial (VE)-cadherin and enhances VE-cadherin function in transfected cells (Nawroth, R., G. Poell, A. Ranft, U. Samulowitz, G. Fachinger, M. Golding, D.T. Shima, U. Deutsch, and D. Vestweber. 2002. EMBO J. 21:4885-4895). We show that VE-PTP is indeed required for endothelial cell contact integrity, because down-regulation of its expression enhanced endothelial cell permeability, augmented leukocyte transmigration, and inhibited VE-cadherin-mediated adhesion. Binding of neutrophils as well as lymphocytes to endothelial cells triggered rapid (5 min) dissociation of VE-PTP from VE-cadherin. This dissociation was only seen with tumor n","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Nov","modification":"2025-04-05T11:51:51.822Z","creation":"2019-03-27T00:19:27Z"},"accession":"S-EPMC2585844","cross_references":{"pubmed":["19015309"],"doi":["10.1084/jem.20080406"]}}