biostudies-literatureDavidson CMNICHD NIH HHS51-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC2592548biostudies-literatureUnknown15(1)The authors test single nucleotide polymorphisms (SNPs) in coding sequences of 12 candidate genes involved in glucose metabolism and obesity for associations with spina bifida. Genotyping was performed on 507 children with spina bifida and their parents plus anonymous control DNAs from Hispanic and Caucasian individuals. The transmission disequilibrium test was performed to test for genetic associations between transmission of alleles and spina bifida in the offspring (P < .05). A statistically significant association between Lys481 of HK1 (G allele), Arg109Lys of LEPR (G allele), and Pro196 of GLUT1 (A allele) was found ( P = .019, .039, and .040, respectively). Three SNPs on 3 genes involved with glucose metabolism and obesity may be associated with increased susceptibility to spina bifida.Reproductive sciences (Thousand Oaks, Calif.)Genes in glucose metabolism and association with spina bifida.PMC2592548P01 HD035946-10P01 HD35946P01 HD035946P01 HD035946-09Tyerman GHDavidson CMNorthrup HFletcher JMTownsend IAu KSKing TMfalseGenes in glucose metabolism and association with spina bifida.The authors test single nucleotide polymorphisms (SNPs) in coding sequences of 12 candidate genes involved in glucose metabolism and obesity for associations with spina bifida. Genotyping was performed on 507 children with spina bifida and their parents plus anonymous control DNAs from Hispanic and Caucasian individuals. The transmission disequilibrium test was performed to test for genetic associations between transmission of alleles and spina bifida in the offspring (P < .05). A statistically significant association between Lys481 of HK1 (G allele), Arg109Lys of LEPR (G allele), and Pro196 of GLUT1 (A allele) was found ( P = .019, .039, and .040, respectively). Three SNPs on 3 genes involved with glucose metabolism and obesity may be associated with increased susceptibility to spina bifida.2008-01-01T00:00:00Z2008 Jan2021-02-19T19:52:53Z2020-08-27T07:00:48ZS-EPMC25925481821235410.1177/1933719107309590