{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["190(24)"],"submitter":["Tsuge Y"],"pubmed_abstract":["In previous work, random genome deletion mutants of Corynebacterium glutamicum R were generated using the insertion sequence (IS) element IS31831 and the Cre/loxP excision system. One of these mutants, C. glutamicum strain RD41, resulting from the deletion of a 10.1-kb genomic region (DeltacgR_1595 through cgR_1604) from the WT strain, showed cell elongation, and several lines appeared on the cell surface (bamboo shape). The morphological changes were suppressed by overexpression of cgR_1596. Single disruption of cgR_1596 in WT C. glutamicum R resulted in morphological changes similar to those observed in the RD41 strain. CgR_1596 has a predicted secretion signal peptide in the amino-terminal region and a predicted NlpC/P60 domain, which is conserved in cell wall hydrolases, in the carboxy"],"journal":["Journal of bacteriology"],"pagination":["8204-14"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2593200"],"repository":["biostudies-literature"],"pubmed_title":["Deletion of cgR_1596 and cgR_2070, encoding NlpC/P60 proteins, causes a defect in cell separation in Corynebacterium glutamicum R."],"pmcid":["PMC2593200"],"pubmed_authors":["Ogino H","Inui M","Yukawa H","Tsuge Y","Teramoto H"],"additional_accession":[]},"is_claimable":false,"name":"Deletion of cgR_1596 and cgR_2070, encoding NlpC/P60 proteins, causes a defect in cell separation in Corynebacterium glutamicum R.","description":"In previous work, random genome deletion mutants of Corynebacterium glutamicum R were generated using the insertion sequence (IS) element IS31831 and the Cre/loxP excision system. One of these mutants, C. glutamicum strain RD41, resulting from the deletion of a 10.1-kb genomic region (DeltacgR_1595 through cgR_1604) from the WT strain, showed cell elongation, and several lines appeared on the cell surface (bamboo shape). The morphological changes were suppressed by overexpression of cgR_1596. Single disruption of cgR_1596 in WT C. glutamicum R resulted in morphological changes similar to those observed in the RD41 strain. CgR_1596 has a predicted secretion signal peptide in the amino-terminal region and a predicted NlpC/P60 domain, which is conserved in cell wall hydrolases, in the carboxy","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Dec","modification":"2025-04-04T13:38:58.775Z","creation":"2019-03-27T00:19:37Z"},"accession":"S-EPMC2593200","cross_references":{"pubmed":["18931118"],"doi":["10.1128/jb.00752-08","10.1128/JB.00752-08"]}}