biostudies-literatureUnknown25(11-12)Drummond JB<h4>Purpose</h4>To study the beta-catenin gene in a group of Mayer-Rokitansky-Küster-Hauser patients.<h4>Methods</h4>Twelve patients with the Mayer-Rokitansky-Küster-Hauser syndrome were included in this study. DNA was extracted from peripheral blood and the region codifying beta-catenin GSK-3beta phosphorylation sites on exon 3 was amplified. PCR products were purified and directly sequenced.<h4>Results</h4>No mutations were found in the GSK-3beta phosphorylation sites on exon 3 of beta-catenin gene in this group of patients with the MRKH syndrome.<h4>Conclusions</h4>beta-catenin gene mutations are an unlikely cause of the MRKH syndrome.Journal of assisted reproduction and genetics511-4https://www.ebi.ac.uk/biostudies/studies/S-EPMC2593771biostudies-literatureMolecular analysis of the beta-catenin gene in patients with the Mayer-Rokitansky-Kuster-Hauser syndrome.PMC2593771Carvalho JSDe Marco LDrummond JBRezende CFPeixoto FCReis FMfalseMolecular analysis of the beta-catenin gene in patients with the Mayer-Rokitansky-Kuster-Hauser syndrome.<h4>Purpose</h4>To study the beta-catenin gene in a group of Mayer-Rokitansky-Küster-Hauser patients.<h4>Methods</h4>Twelve patients with the Mayer-Rokitansky-Küster-Hauser syndrome were included in this study. DNA was extracted from peripheral blood and the region codifying beta-catenin GSK-3beta phosphorylation sites on exon 3 was amplified. PCR products were purified and directly sequenced.<h4>Results</h4>No mutations were found in the GSK-3beta phosphorylation sites on exon 3 of beta-catenin gene in this group of patients with the MRKH syndrome.<h4>Conclusions</h4>beta-catenin gene mutations are an unlikely cause of the MRKH syndrome.2008-01-01T00:00:00Z2008 Nov-Dec2025-06-01T01:15:22.33Z2025-06-01T01:15:22.33ZS-EPMC25937711897919510.1007/s10815-008-9261-y