{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Johnston CA"],"funding":["NEI NIH HHS","NIGMS NIH HHS"],"pagination":["11390-400"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2597383"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(38)"],"pubmed_abstract":["G-proteins cycle between an inactive GDP-bound state and an active GTP-bound state, serving as molecular switches that coordinate cellular signaling. We recently used phage display to identify a series of peptides that bind G alpha subunits in a nucleotide-dependent manner [Johnston, C. A., Willard, F. S., Jezyk, M. R., Fredericks, Z., Bodor, E. T., Jones, M. B., Blaesius, R., Watts, V. J., Harden, T. K., Sondek, J., Ramer, J. K., and Siderovski, D. P. (2005) Structure 13, 1069-1080]. Here we describe the structural features and functions of KB-1753, a peptide that binds selectively to GDP x AlF4(-)- and GTPgammaS-bound states of G alpha(i) subunits. KB-1753 blocks interaction of G alpha(transducin) with its effector, cGMP phosphodiesterase, and inhibits transducin-mediated activation of c"],"journal":["Biochemistry"],"pubmed_title":["Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer."],"pmcid":["PMC2597383"],"funding_grant_id":["EY12859","1 F32 GM076944","R01 EY012859-06","F32 GM076944-02","R01 GM074268","R01 GM074268-03","F32 GM076944-01","F32 GM076944","R01 GM074268-01A1","R01 EY012859","R01 GM074268-02"],"pubmed_authors":["Lobanova ES","Blaesius R","Ramer JK","Kuhlman B","Arshavsky VY","Fredericks Z","Johnston CA","Low J","Willard FS","Siderovski DP","Shavkunov AS"],"additional_accession":[]},"is_claimable":false,"name":"Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer.","description":"G-proteins cycle between an inactive GDP-bound state and an active GTP-bound state, serving as molecular switches that coordinate cellular signaling. We recently used phage display to identify a series of peptides that bind G alpha subunits in a nucleotide-dependent manner [Johnston, C. A., Willard, F. S., Jezyk, M. R., Fredericks, Z., Bodor, E. T., Jones, M. B., Blaesius, R., Watts, V. J., Harden, T. K., Sondek, J., Ramer, J. K., and Siderovski, D. P. (2005) Structure 13, 1069-1080]. Here we describe the structural features and functions of KB-1753, a peptide that binds selectively to GDP x AlF4(-)- and GTPgammaS-bound states of G alpha(i) subunits. KB-1753 blocks interaction of G alpha(transducin) with its effector, cGMP phosphodiesterase, and inhibits transducin-mediated activation of c","dates":{"release":"2006-01-01T00:00:00Z","publication":"2006 Sep","modification":"2025-04-05T15:40:41.951Z","creation":"2019-03-27T00:19:42Z"},"accession":"S-EPMC2597383","cross_references":{"pubmed":["16981699"],"doi":["10.1021/bi0613832"]}}