{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shang S"],"funding":["NIGMS NIH HHS"],"pagination":["1895-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2597797"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(10)"],"pubmed_abstract":["An efficient systematic approach to the diversity-oriented synthesis of polyketides has been developed to provide both skeletal and stereochemical diversity. Each synthetic intermediate is also a desired polyketide fragment and no protecting group manipulations are required. A first-generation synthesis provides a 74-membered polyketide library comprising six different skeletal classes, each in one to five steps from propargylic alcohol precursors. A study of epoxyol opening reactions revealed unusual reactivity trends based on epoxide configuration."],"journal":["Organic letters"],"pubmed_title":["A unified synthetic approach to polyketides having both skeletal and stereochemical diversity."],"pmcid":["PMC2597797"],"funding_grant_id":["P41 GM076267-02","P41 GM076267"],"pubmed_authors":["Ambrosini LM","Macks DE","Iwadare H","Tan DS","Shang S"],"additional_accession":[]},"is_claimable":false,"name":"A unified synthetic approach to polyketides having both skeletal and stereochemical diversity.","description":"An efficient systematic approach to the diversity-oriented synthesis of polyketides has been developed to provide both skeletal and stereochemical diversity. Each synthetic intermediate is also a desired polyketide fragment and no protecting group manipulations are required. A first-generation synthesis provides a 74-membered polyketide library comprising six different skeletal classes, each in one to five steps from propargylic alcohol precursors. A study of epoxyol opening reactions revealed unusual reactivity trends based on epoxide configuration.","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 May","modification":"2020-10-31T09:40:05Z","creation":"2019-03-27T00:19:44Z"},"accession":"S-EPMC2597797","cross_references":{"pubmed":["17439132"],"doi":["10.1021/ol070405p"]}}