{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["44(8)"],"submitter":["Dumont J"],"pubmed_abstract":["BACKGROUND: Recently, it was suggested that arginase (ARG)1 plays an important role in atherogenesis. However, because of its complex functions depending on vascular cell type, its impact on atherogenesis remains unclear. OBJECTIVE: To evaluate the association between ARG1 polymorphisms and phenotypes related to atherosclerosis. METHODS: Among 10 ARG1 polymorphisms selected from databases, 4 single-nucleotide polymorphisms (rs2781666; rs2781667; rs2781668; rs17599586) were tested for association with myocardial infarction (MI) in a case-control study (350 cases vs 581 controls), and with common carotid artery (CCA) intima-media thickness (CCA-IMT) in an independent sample of 963 subjects (Etude du Vieillissement Artériel (EVA) study). RESULTS: The genotype distribution of the rs2781666 G/T polymorphism differed significantly between MI cases and controls (p = 0.005), and the risk of MI was consistently increased for both GT heterozygotes (OR (95% CI) 1.5 (1.1 to 2.0)) and TT homozygotes (OR (95% CI) 2.2 (1.1 to 4.4)). In the EVA study, the rs2781666 polymorphism was also associated with an increase in CCA-IMT (p = 0.010), a surrogate marker of MI. CONCLUSIONS: The ARG1 rs2781666 polymorphism was consistently associated with MI and an increased CCA-IMT. These findings reinforce the hypothesis of a significant role of ARG1 in vascular pathophysiology."],"journal":["Journal of medical genetics"],"pagination":["526-31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2597928"],"repository":["biostudies-literature"],"pubmed_title":["Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness."],"pmcid":["PMC2597928"],"pubmed_authors":["Brousseau T","Cottel D","Montaye M","Zureik M","Ducimetiere P","Dumont J","Amouyel P"],"additional_accession":[]},"is_claimable":false,"name":"Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness.","description":"BACKGROUND: Recently, it was suggested that arginase (ARG)1 plays an important role in atherogenesis. However, because of its complex functions depending on vascular cell type, its impact on atherogenesis remains unclear. OBJECTIVE: To evaluate the association between ARG1 polymorphisms and phenotypes related to atherosclerosis. METHODS: Among 10 ARG1 polymorphisms selected from databases, 4 single-nucleotide polymorphisms (rs2781666; rs2781667; rs2781668; rs17599586) were tested for association with myocardial infarction (MI) in a case-control study (350 cases vs 581 controls), and with common carotid artery (CCA) intima-media thickness (CCA-IMT) in an independent sample of 963 subjects (Etude du Vieillissement Artériel (EVA) study). RESULTS: The genotype distribution of the rs2781666 G/T polymorphism differed significantly between MI cases and controls (p = 0.005), and the risk of MI was consistently increased for both GT heterozygotes (OR (95% CI) 1.5 (1.1 to 2.0)) and TT homozygotes (OR (95% CI) 2.2 (1.1 to 4.4)). In the EVA study, the rs2781666 polymorphism was also associated with an increase in CCA-IMT (p = 0.010), a surrogate marker of MI. CONCLUSIONS: The ARG1 rs2781666 polymorphism was consistently associated with MI and an increased CCA-IMT. These findings reinforce the hypothesis of a significant role of ARG1 in vascular pathophysiology.","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Aug","modification":"2021-02-20T00:51:25Z","creation":"2019-03-27T00:19:44Z"},"accession":"S-EPMC2597928","cross_references":{"pubmed":["17369504"],"doi":["10.1136/jmg.2006.047449"]}}