biostudies-literatureUnknown4(1)Han PHuman BRCA1 (BRreast CAncer susceptible gene1) is known to involve in cell cycle control, transcriptional regulation, DNA recombination, DNA repair and many other processes. hBARD1 (BRCA1-Associated Ring Domain 1) forms heterodimer via its N-terminal conserved RING domain with BRCA1. In Arabidopsis, two genes, At4g21070 and At1g04020, that share N-terminal RING domain and C-terminal BRCT (for BRCA1 C-Terminal) domains with no substantial similarities for other motifs, have been identified. AtBRCA1 was induced by gamma-ray while AtBARD1 was required for DNA repair. Recently, we find that AtBARD1 may function to confine WUS transcription in the shoot apical meristem organization center, together with the ATPase-dependent chromatin remodeling factor, SYD. In bard1-3 Arabidopsis knockout mutanPlant signaling & behavior52-4https://www.ebi.ac.uk/biostudies/studies/S-EPMC2634073biostudies-literatureBARD1 may be renamed ROW1 because it functions mainly as a REPRESSOR OF WUSCHEL1.PMC2634073Han PZhu YXfalseBARD1 may be renamed ROW1 because it functions mainly as a REPRESSOR OF WUSCHEL1.Human BRCA1 (BRreast CAncer susceptible gene1) is known to involve in cell cycle control, transcriptional regulation, DNA recombination, DNA repair and many other processes. hBARD1 (BRCA1-Associated Ring Domain 1) forms heterodimer via its N-terminal conserved RING domain with BRCA1. In Arabidopsis, two genes, At4g21070 and At1g04020, that share N-terminal RING domain and C-terminal BRCT (for BRCA1 C-Terminal) domains with no substantial similarities for other motifs, have been identified. AtBRCA1 was induced by gamma-ray while AtBARD1 was required for DNA repair. Recently, we find that AtBARD1 may function to confine WUS transcription in the shoot apical meristem organization center, together with the ATPase-dependent chromatin remodeling factor, SYD. In bard1-3 Arabidopsis knockout mutan2009-01-01T00:00:00Z2009 Jan2025-05-31T23:33:24.904Z2025-05-31T23:33:24.904ZS-EPMC26340731970470810.4161/psb.4.1.7312