biostudies-literatureGarcia-Arriaga MNIGMS NIH HHS10492-3https://www.ebi.ac.uk/biostudies/studies/S-EPMC2646872biostudies-literatureUnknown130(32)We report the self-assembly of a hydrophilic 8-(m-acetylphenyl)-2'-deoxyguanosine (mAG) derivative into a discrete and thermally stable hexadecameric supramolecule in aqueous media. We demonstrate that this hexadecamer is isostructural to the one formed by a related lipophilic derivative in organic media. This mAG moiety represents a rare example of a small-molecule recognition motif that is capable of assembling isostructurally and with high fidelity in both organic and aqueous media.Journal of the American Chemical SocietyIsostructural self-assembly of 2'-deoxyguanosine derivatives in aqueous and organic media.PMC2646872R25 GM0611512R25GM61151S06 GM0081022506GM08102Garcia-Arriaga MHobley GRivera JMfalseIsostructural self-assembly of 2'-deoxyguanosine derivatives in aqueous and organic media.We report the self-assembly of a hydrophilic 8-(m-acetylphenyl)-2'-deoxyguanosine (mAG) derivative into a discrete and thermally stable hexadecameric supramolecule in aqueous media. We demonstrate that this hexadecamer is isostructural to the one formed by a related lipophilic derivative in organic media. This mAG moiety represents a rare example of a small-molecule recognition motif that is capable of assembling isostructurally and with high fidelity in both organic and aqueous media.2008-01-01T00:00:00Z2008 Aug2026-03-16T16:28:55.573Z2019-03-27T00:20:52ZS-EPMC26468721864291710.1021/ja8039019