{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2(1)"],"submitter":["Cavaliere V"],"pubmed_abstract":["Chemotherapy aims to limit proliferation and induce apoptotic cell death in tumor cells. Owing to blockade of signaling pathways involved in cell survival and proliferation, nuclear factor kappaB (NF-kappaB) inhibitors can induce apoptosis in a number of hematological malignancies. The efficacy of conventional chemotherapeutic drugs, such as vincristine (VCR) and doxorubicine (DOX), may be enhanced with combined therapy based on NF-kappaB modulation. In this study, we evaluated the effect of caffeic acid phenylethyl ester (CAPE) and MG-132, two nonspecific NF-kappaB inhibitors, and conventional chemotherapeutics drugs DOX and VCR on cell proliferation and apoptosis induction on a lymphoblastoid B-cell line, PL104, established and characterized in our laboratory. CAPE and MG-132 treatment s"],"journal":["Translational oncology"],"pagination":["46-58"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2647702"],"repository":["biostudies-literature"],"pubmed_title":["Caffeic Acid Phenylethyl Ester and MG-132 Have Apoptotic and Antiproliferative Effects on Leukemic Cells But Not on Normal Mononuclear Cells."],"pmcid":["PMC2647702"],"pubmed_authors":["Gargallo P","Larripa I","Pardo ML","Papademetrio DL","Lorenzetti M","Cavaliere V","Monreal MB","Valva P","Blanco GA","Alvarez EM","Preciado MV","Hajos SE"],"additional_accession":[]},"is_claimable":false,"name":"Caffeic Acid Phenylethyl Ester and MG-132 Have Apoptotic and Antiproliferative Effects on Leukemic Cells But Not on Normal Mononuclear Cells.","description":"Chemotherapy aims to limit proliferation and induce apoptotic cell death in tumor cells. Owing to blockade of signaling pathways involved in cell survival and proliferation, nuclear factor kappaB (NF-kappaB) inhibitors can induce apoptosis in a number of hematological malignancies. The efficacy of conventional chemotherapeutic drugs, such as vincristine (VCR) and doxorubicine (DOX), may be enhanced with combined therapy based on NF-kappaB modulation. In this study, we evaluated the effect of caffeic acid phenylethyl ester (CAPE) and MG-132, two nonspecific NF-kappaB inhibitors, and conventional chemotherapeutics drugs DOX and VCR on cell proliferation and apoptosis induction on a lymphoblastoid B-cell line, PL104, established and characterized in our laboratory. CAPE and MG-132 treatment s","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Mar","modification":"2025-04-04T07:58:31.124Z","creation":"2019-03-27T00:20:53Z"},"accession":"S-EPMC2647702","cross_references":{"pubmed":["19252751"],"doi":["10.1593/tlo.08202"]}}