{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4"],"submitter":["Yutin N"],"funding":["Intramural NIH HHS"],"pubmed_abstract":["<h4>Background</h4>Phagocytosis, that is, engulfment of large particles by eukaryotic cells, is found in diverse organisms and is often thought to be central to the very origin of the eukaryotic cell, in particular, for the acquisition of bacterial endosymbionts including the ancestor of the mitochondrion.<h4>Results</h4>Comparisons of the sets of proteins implicated in phagocytosis in different eukaryotes reveal extreme diversity, with very few highly conserved components that typically do not possess readily identifiable prokaryotic homologs. Nevertheless, phylogenetic analysis of those proteins for which such homologs do exist yields clues to the possible origin of phagocytosis. The central finding is that a subset of archaea encode actins that are not only monophyletic with eukaryotic "],"journal":["Biology direct"],"pagination":["9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2651865"],"repository":["biostudies-literature"],"pubmed_title":["The origins of phagocytosis and eukaryogenesis."],"pmcid":["PMC2651865"],"pubmed_authors":["Wolf MY","Wolf YI","Koonin EV","Yutin N"],"additional_accession":[]},"is_claimable":false,"name":"The origins of phagocytosis and eukaryogenesis.","description":"<h4>Background</h4>Phagocytosis, that is, engulfment of large particles by eukaryotic cells, is found in diverse organisms and is often thought to be central to the very origin of the eukaryotic cell, in particular, for the acquisition of bacterial endosymbionts including the ancestor of the mitochondrion.<h4>Results</h4>Comparisons of the sets of proteins implicated in phagocytosis in different eukaryotes reveal extreme diversity, with very few highly conserved components that typically do not possess readily identifiable prokaryotic homologs. Nevertheless, phylogenetic analysis of those proteins for which such homologs do exist yields clues to the possible origin of phagocytosis. The central finding is that a subset of archaea encode actins that are not only monophyletic with eukaryotic ","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Feb","modification":"2026-03-16T16:39:05.485Z","creation":"2025-08-31T03:08:37.494Z"},"accession":"S-EPMC2651865","cross_references":{"pubmed":["19245710"],"doi":["10.1186/1745-6150-4-9"]}}