{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(3)"],"submitter":["Sutherland GT"],"pubmed_abstract":["The study of Parkinson's disease (PD), like other complex neurodegenerative disorders, is limited by access to brain tissue from patients with a confirmed diagnosis. Alternatively the study of peripheral tissues may offer some insight into the molecular basis of disease susceptibility and progression, but this approach still relies on brain tissue to benchmark relevant molecular changes against. Several studies have reported whole-genome expression profiling in post-mortem brain but reported concordance between these analyses is lacking. Here we apply a standardised pathway analysis to seven independent case-control studies, and demonstrate increased concordance between data sets. Moreover data convergence increased when the analysis was limited to the five substantia nigra (SN) data sets;"],"journal":["PloS one"],"pagination":["e4955"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2654916"],"repository":["biostudies-literature"],"pubmed_title":["A cross-study transcriptional analysis of Parkinson's disease."],"pmcid":["PMC2654916"],"pubmed_authors":["Mellick GD","Sutherland GT","Wells CA","Mackay-Sim A","Matigian NA","Anderson MJ","Chalk AM","Silburn PA"],"additional_accession":[]},"is_claimable":false,"name":"A cross-study transcriptional analysis of Parkinson's disease.","description":"The study of Parkinson's disease (PD), like other complex neurodegenerative disorders, is limited by access to brain tissue from patients with a confirmed diagnosis. Alternatively the study of peripheral tissues may offer some insight into the molecular basis of disease susceptibility and progression, but this approach still relies on brain tissue to benchmark relevant molecular changes against. Several studies have reported whole-genome expression profiling in post-mortem brain but reported concordance between these analyses is lacking. Here we apply a standardised pathway analysis to seven independent case-control studies, and demonstrate increased concordance between data sets. Moreover data convergence increased when the analysis was limited to the five substantia nigra (SN) data sets;","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009","modification":"2026-04-29T13:10:24.5Z","creation":"2026-04-07T15:15:32.559Z"},"accession":"S-EPMC2654916","cross_references":{"pubmed":["19305504"],"doi":["10.1371/journal.pone.0004955"]}}