{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jackson-Fisher AJ"],"funding":["NCI NIH HHS"],"pagination":["R96"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2656891"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(6)"],"pubmed_abstract":["Introduction
The receptor ErbB3/HER3 is often over-expressed in human breast cancers, frequently in conjunction with over-expression of the proto-oncogene ERBB2/HER2/NEU. Although the prognostic/predictive value of ErbB3 expression in breast cancer is unclear, ErbB3 is known to contribute to therapeutic resistance. Understanding ErbB3 functions in the normal mammary gland will help to explain its role in cancer etiology and as a modulator of signaling responses to the mammary oncogene ERBB2.Methods
To investigate the roles of ErbB3 in mouse mammary gland development, we transplanted mammary buds from ErbB3-/- embryos into the cleared mammary fat pads of wild-type immunocompromised mice. Effects on ductal outgrowth were analyzed at 4 weeks, 7 weeks and 20 weeks after transpl"],"journal":["Breast cancer research : BCR"],"pubmed_title":["ErbB3 is required for ductal morphogenesis in the mouse mammary gland."],"pmcid":["PMC2656891"],"funding_grant_id":["R01CA45708","R01 CA045708"],"pubmed_authors":["Stern DF","Bellinger G","Breindel JL","Duong JK","Jackson-Fisher AJ","Booth CJ","Tavassoli FA"],"additional_accession":[]},"is_claimable":false,"name":"ErbB3 is required for ductal morphogenesis in the mouse mammary gland.","description":"Introduction
The receptor ErbB3/HER3 is often over-expressed in human breast cancers, frequently in conjunction with over-expression of the proto-oncogene ERBB2/HER2/NEU. Although the prognostic/predictive value of ErbB3 expression in breast cancer is unclear, ErbB3 is known to contribute to therapeutic resistance. Understanding ErbB3 functions in the normal mammary gland will help to explain its role in cancer etiology and as a modulator of signaling responses to the mammary oncogene ERBB2.Methods
To investigate the roles of ErbB3 in mouse mammary gland development, we transplanted mammary buds from ErbB3-/- embryos into the cleared mammary fat pads of wild-type immunocompromised mice. Effects on ductal outgrowth were analyzed at 4 weeks, 7 weeks and 20 weeks after transpl","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008","modification":"2025-04-04T09:28:10.238Z","creation":"2019-03-27T00:21:17Z"},"accession":"S-EPMC2656891","cross_references":{"pubmed":["19019207"],"doi":["10.1186/bcr2198"]}}