{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(5)"],"submitter":["Shembade N"],"pubmed_abstract":["The RING domain protein RNF11 is overexpressed in breast cancers and promotes tumour growth factor-beta (TGF-beta) signalling. RNF11 has been proposed to regulate TGF-beta signalling by interacting with HECT- and SCF-type E3 ligases; however, the role of RNF11 in other signalling pathways is poorly understood. Here, we demonstrate a novel function of RNF11 as a negative regulator of NF-kappaB and jun N-terminal kinase (JNK) signalling pathways. Knockdown of RNF11 with siRNA resulted in persistent tumour necrosis factor (TNF)- and lipopolysaccharide (LPS)-mediated NF-kappaB and JNK signalling. RNF11 interacted with the NF-kappaB inhibitor A20 and its regulatory protein TAX1BP1 in a stimulus-dependent manner. RNF11 negatively regulated RIP1 and TRAF6 ubiquitination upon stimulation with TNF "],"journal":["The EMBO journal"],"pagination":["513-22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2657574"],"repository":["biostudies-literature"],"pubmed_title":["The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling."],"pmcid":["PMC2657574"],"pubmed_authors":["Shembade N","Parvatiyar K","Harhaj NS","Harhaj EW"],"additional_accession":[]},"is_claimable":false,"name":"The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling.","description":"The RING domain protein RNF11 is overexpressed in breast cancers and promotes tumour growth factor-beta (TGF-beta) signalling. RNF11 has been proposed to regulate TGF-beta signalling by interacting with HECT- and SCF-type E3 ligases; however, the role of RNF11 in other signalling pathways is poorly understood. Here, we demonstrate a novel function of RNF11 as a negative regulator of NF-kappaB and jun N-terminal kinase (JNK) signalling pathways. Knockdown of RNF11 with siRNA resulted in persistent tumour necrosis factor (TNF)- and lipopolysaccharide (LPS)-mediated NF-kappaB and JNK signalling. RNF11 interacted with the NF-kappaB inhibitor A20 and its regulatory protein TAX1BP1 in a stimulus-dependent manner. RNF11 negatively regulated RIP1 and TRAF6 ubiquitination upon stimulation with TNF ","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Mar","modification":"2025-04-04T19:12:48.38Z","creation":"2019-03-27T00:21:19Z"},"accession":"S-EPMC2657574","cross_references":{"pubmed":["19131965"],"doi":["10.1038/emboj.2008.285"]}}