{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Molina H"],"funding":["NCRR NIH HHS","NHLBI NIH HHS","NCI NIH HHS"],"pagination":["4825-35"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2664833"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["80(13)"],"pubmed_abstract":["Electron transfer dissociation (ETD) is a recently introduced mass spectrometric technique which has proven to be an excellent tool for the elucidation of labile post-translational modifications such as phosphorylation and O-GlcNAcylation of serine and threonine residues. However, unlike collision induced dissociation (CID), which has been studied for decades, the intricacies of ETD-based fragmentation have not yet been firmly established or systematically addressed. In this analysis, we have systematically compared the CID and ETD fragmentation patterns for the large majority of the peptides that do not contain such labile modifications. Using a standard 48 protein mix, we were able to measure false-positive rates for the experiments and also assess a large number of peptides for a detail"],"journal":["Analytical chemistry"],"pubmed_title":["Comprehensive comparison of collision induced dissociation and electron transfer dissociation."],"pmcid":["PMC2664833"],"funding_grant_id":["U54 RR020839","N01-HV-28180","U54RR020839","N01HV28180","R01 CA106424","R01CA106424"],"pubmed_authors":["Matthiesen R","Pandey A","Molina H","Kandasamy K"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive comparison of collision induced dissociation and electron transfer dissociation.","description":"Electron transfer dissociation (ETD) is a recently introduced mass spectrometric technique which has proven to be an excellent tool for the elucidation of labile post-translational modifications such as phosphorylation and O-GlcNAcylation of serine and threonine residues. However, unlike collision induced dissociation (CID), which has been studied for decades, the intricacies of ETD-based fragmentation have not yet been firmly established or systematically addressed. In this analysis, we have systematically compared the CID and ETD fragmentation patterns for the large majority of the peptides that do not contain such labile modifications. Using a standard 48 protein mix, we were able to measure false-positive rates for the experiments and also assess a large number of peptides for a detail","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Jul","modification":"2026-03-16T16:25:38.413Z","creation":"2019-03-27T00:21:37Z"},"accession":"S-EPMC2664833","cross_references":{"pubmed":["18540640"],"doi":["10.1021/ac8007785"]}}