{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Kurscheid S"],"pubmed_abstract":["<h4>Background</h4>The Arthropods are a diverse group of organisms including Chelicerata (ticks, mites, spiders), Crustacea (crabs, shrimps), and Insecta (flies, mosquitoes, beetles, silkworm). The cattle tick, Rhipicephalus (Boophilus) microplus, is an economically significant ectoparasite of cattle affecting cattle industries world wide. With the availability of sequence reads from the first Chelicerate genome project (the Ixodes scapularis tick) and extensive R. microplus ESTs, we investigated evidence for putative RNAi proteins and studied RNA interference in tick cell cultures and adult female ticks targeting Drosophila homologues with known cell viability phenotype.<h4>Results</h4>We screened 13,643 R. microplus ESTs and I. scapularis genome reads to identify RNAi related proteins in"],"journal":["BMC molecular biology"],"pagination":["26"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2676286"],"repository":["biostudies-literature"],"pubmed_title":["Evidence of a tick RNAi pathway by comparative genomics and reverse genetics screen of targets with known loss-of-function phenotypes in Drosophila."],"pmcid":["PMC2676286"],"pubmed_authors":["Kurscheid S","Barrero RA","Doogan VJ","Bellgard MI","Rodriguez Valle M","Lew-Tabor AE","Bruyeres AG","Munderloh UG","Guerrero FD"],"additional_accession":[]},"is_claimable":false,"name":"Evidence of a tick RNAi pathway by comparative genomics and reverse genetics screen of targets with known loss-of-function phenotypes in Drosophila.","description":"<h4>Background</h4>The Arthropods are a diverse group of organisms including Chelicerata (ticks, mites, spiders), Crustacea (crabs, shrimps), and Insecta (flies, mosquitoes, beetles, silkworm). The cattle tick, Rhipicephalus (Boophilus) microplus, is an economically significant ectoparasite of cattle affecting cattle industries world wide. With the availability of sequence reads from the first Chelicerate genome project (the Ixodes scapularis tick) and extensive R. microplus ESTs, we investigated evidence for putative RNAi proteins and studied RNA interference in tick cell cultures and adult female ticks targeting Drosophila homologues with known cell viability phenotype.<h4>Results</h4>We screened 13,643 R. microplus ESTs and I. scapularis genome reads to identify RNAi related proteins in","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Mar","modification":"2026-04-18T11:11:51.135Z","creation":"2026-04-07T14:35:43.06Z"},"accession":"S-EPMC2676286","cross_references":{"pubmed":["19323841"],"doi":["10.1186/1471-2199-10-26"]}}