{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Whitwell JL"],"funding":["NICHD NIH HHS","NIA NIH HHS","NCRR NIH HHS","NINDS NIH HHS"],"pagination":["813-20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2677544"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["72(9)"],"pubmed_abstract":["<h4>Objective</h4>To compare patterns of gray matter loss in subjects with mutations in the progranulin (PGRN) gene to subjects with mutations in the microtubule-associated protein tau (MAPT) gene.<h4>Methods</h4>We identified all subjects seen at the Mayo Clinic, Rochester, MN, who had screened positive for mutations in PGRN or MAPT and had a head MRI. Twelve cases with mutations in the PGRN gene were matched by time from disease onset to scan to 12 subjects with mutations in the MAPT gene. Voxel-based morphometry was used to assess patterns of gray matter loss in the PGRN and MAPT groups compared to a control cohort, and compared to each other. MAPT subjects were younger than the PGRN subjects; therefore, each group was also compared to a specific age-matched control group.<h4>Results</h"],"journal":["Neurology"],"pubmed_title":["Voxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN."],"pmcid":["PMC2677544"],"funding_grant_id":["C06 RR018898","P50-AG16574","P50 NS40256","K12 HD49078","U01-AG06786","R01-AG11378"],"pubmed_authors":["Baker M","Wszolek ZK","Josephs KA","Whitwell JL","Jack CR","Rademakers R","Ivnik RJ","Knopman DS","Boeve BF","Senjem ML","Petersen RC"],"additional_accession":[]},"is_claimable":false,"name":"Voxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN.","description":"<h4>Objective</h4>To compare patterns of gray matter loss in subjects with mutations in the progranulin (PGRN) gene to subjects with mutations in the microtubule-associated protein tau (MAPT) gene.<h4>Methods</h4>We identified all subjects seen at the Mayo Clinic, Rochester, MN, who had screened positive for mutations in PGRN or MAPT and had a head MRI. Twelve cases with mutations in the PGRN gene were matched by time from disease onset to scan to 12 subjects with mutations in the MAPT gene. Voxel-based morphometry was used to assess patterns of gray matter loss in the PGRN and MAPT groups compared to a control cohort, and compared to each other. MAPT subjects were younger than the PGRN subjects; therefore, each group was also compared to a specific age-matched control group.<h4>Results</h","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Mar","modification":"2025-04-05T13:13:17.352Z","creation":"2019-03-27T00:22:10Z"},"accession":"S-EPMC2677544","cross_references":{"pubmed":["19255408"],"doi":["10.1212/01.wnl.0000343851.46573.67"]}}