biostudies-literatureWhitwell JLNICHD NIH HHSNIA NIH HHSNCRR NIH HHSNINDS NIH HHS813-20https://www.ebi.ac.uk/biostudies/studies/S-EPMC2677544biostudies-literatureUnknown72(9)<h4>Objective</h4>To compare patterns of gray matter loss in subjects with mutations in the progranulin (PGRN) gene to subjects with mutations in the microtubule-associated protein tau (MAPT) gene.<h4>Methods</h4>We identified all subjects seen at the Mayo Clinic, Rochester, MN, who had screened positive for mutations in PGRN or MAPT and had a head MRI. Twelve cases with mutations in the PGRN gene were matched by time from disease onset to scan to 12 subjects with mutations in the MAPT gene. Voxel-based morphometry was used to assess patterns of gray matter loss in the PGRN and MAPT groups compared to a control cohort, and compared to each other. MAPT subjects were younger than the PGRN subjects; therefore, each group was also compared to a specific age-matched control group.<h4>Results</hNeurologyVoxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN.PMC2677544C06 RR018898P50-AG16574P50 NS40256K12 HD49078U01-AG06786R01-AG11378Baker MWszolek ZKJosephs KAWhitwell JLJack CRRademakers RIvnik RJKnopman DSBoeve BFSenjem MLPetersen RCfalseVoxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN.<h4>Objective</h4>To compare patterns of gray matter loss in subjects with mutations in the progranulin (PGRN) gene to subjects with mutations in the microtubule-associated protein tau (MAPT) gene.<h4>Methods</h4>We identified all subjects seen at the Mayo Clinic, Rochester, MN, who had screened positive for mutations in PGRN or MAPT and had a head MRI. Twelve cases with mutations in the PGRN gene were matched by time from disease onset to scan to 12 subjects with mutations in the MAPT gene. Voxel-based morphometry was used to assess patterns of gray matter loss in the PGRN and MAPT groups compared to a control cohort, and compared to each other. MAPT subjects were younger than the PGRN subjects; therefore, each group was also compared to a specific age-matched control group.<h4>Results</h2009-01-01T00:00:00Z2009 Mar2025-04-05T13:13:17.352Z2019-03-27T00:22:10ZS-EPMC26775441925540810.1212/01.wnl.0000343851.46573.67