biostudies-literatureJack CRNIA NIH HHSMedical Research CouncilNational Institute for Health Research (NIHR)1355-65https://www.ebi.ac.uk/biostudies/studies/S-EPMC2677798biostudies-literatureUnknown132(Pt 5)The purpose of this study was to use serial imaging to gain insight into the sequence of pathologic events in Alzheimer's disease, and the clinical features associated with this sequence. We measured change in amyloid deposition over time using serial (11)C Pittsburgh compound B (PIB) positron emission tomography and progression of neurodegeneration using serial structural magnetic resonance imaging. We studied 21 healthy cognitively normal subjects, 32 with amnestic mild cognitive impairment and 8 with Alzheimer's disease. Subjects were drawn from two sources--ongoing longitudinal registries at Mayo Clinic, and the Alzheimer's disease Neuroimaging Initiative (ADNI). All subjects underwent clinical assessments, MRI and PIB studies at two time points, approximately one year apart. PIB retenBrain : a journal of neurologySerial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease.PMC2677798R01 AG027342U01 AG06786P01 AG010491-14G0601846P30 AG019610P01 AG010491NF-SI-0508-10123AG024904R01 AG11378U19 AG010483P50 AG16574Strauman SCrawford KCarmichael OLee VMVorobik RHighum DBach JSafirstein BEGrossman HChertkow HAisen PSDeCarli CLord JLMontine TVillanueva-Meyer JPetrella JRFrank RSpann BDuara RFletcher Rde Leon MJCelmins DWu CKPawluczyk SMesner SFletcher ELah JJHsiung GYDeVous MPotter HDeKosky STMintun MAJohnson KBNeu SFeldman HJohnson KALee TYDoraiswamy PMBernick CPreda AShiung MMBoeve BFAsthana SAlbert MSCohen RHosein COtt BRBurns JMMacAvoy MGQuinn JMesulam MSmith CDBadger BFleisher ASKoeppe RABifano LAMcAdams-Ortiz CFarlow MGreen RCReiman EMIsaacson RdeToledo-Morrell LChen KSilverman DHBell KLAuchus APKemp BJCarlsson CMPetersen RCZimmerman EAClark CMSadowsky CAnderson HSSenjem MLJohnson KLaubinger MMMarenberg MEJohnson NSchuff NDiaz-Arrastia RRusinek HKertesz AFriedland RPHonig LSShah RCVillena TJohnson HJagust WSaykin AJGamst AHeidebrink JLRosen AScharre DWAnderson KAlzheimer's Disease Neuroimaging InitiativePedroso JPotkin SGThompson PBandy DKittur SGiven CAPetersen RJayam-Trouth AMirje SGitelman DKornak JDe Santi SMBehan KEPham CTinklenberg JFox NVanderswag HIsmail MSThal LStern YBartzokis GKaye JSabbagh MConnor DNorbash AAnders DTrost DWiste HJStern JPare NBernstein MKilliany RMolchan SKataki MOakley MGunter JLAiello MTang CToga AWPearlson GJohnson SCSantulli RBFelmlee JPorsteinsson AShaw LHake AMSchneider SAshford WKnopman DSWeiner MBeversdorf DQSnyder PJSchneider LBlank KToroney JWeigand SDSperling RABlack SCaldwell CGiordano AHuang JBeckett LJack CRHerring SNunez JRentz DMObradov SFoster NWang Pvan Dyck CHGandy SMulnard RAKachaturian ZCramer SCGriffith RLu PHMarson DGraham SSimpson DMPotter WZWilliamson JDKorecka MHarvey DHardy PMcCallum CMartin-Cook KHendin BAWilks KLDoody RSChowdhury MBrown ADAlexander GRovner BWBorrie MBergman HRogers JTariot PNCellar JSLevey AIObisesan TOParfitt FTrojanowki JMorris JCRaj BANguyen DAssaly MLowe VJSink KMfalseSerial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease.The purpose of this study was to use serial imaging to gain insight into the sequence of pathologic events in Alzheimer's disease, and the clinical features associated with this sequence. We measured change in amyloid deposition over time using serial (11)C Pittsburgh compound B (PIB) positron emission tomography and progression of neurodegeneration using serial structural magnetic resonance imaging. We studied 21 healthy cognitively normal subjects, 32 with amnestic mild cognitive impairment and 8 with Alzheimer's disease. Subjects were drawn from two sources--ongoing longitudinal registries at Mayo Clinic, and the Alzheimer's disease Neuroimaging Initiative (ADNI). All subjects underwent clinical assessments, MRI and PIB studies at two time points, approximately one year apart. PIB reten2009-01-01T00:00:00Z2009 May2025-04-04T07:58:50.566Z2019-03-27T00:22:10ZS-EPMC26777981933925310.1093/brain/awp062