biostudies-literatureCheng CYIntramural NIH HHSNICHD NIH HHSNIDDK NIH HHSNIA NIH HHSNCRR NIH HHSNIEHS NIH HHSNHLBI NIH HHSNHGRI NIH HHSNCI NIH HHSNIAMS NIH HHSe1000490https://www.ebi.ac.uk/biostudies/studies/S-EPMC2679192biostudies-literatureUnknown5(5)The prevalence of obesity (body mass index (BMI) > or =30 kg/m(2)) is higher in African Americans than in European Americans, even after adjustment for socioeconomic factors, suggesting that genetic factors may explain some of the difference. To identify genetic loci influencing BMI, we carried out a pooled analysis of genome-wide admixture mapping scans in 15,280 African Americans from 14 epidemiologic studies. Samples were genotyped at a median of 1,411 ancestry-informative markers. After adjusting for age, sex, and study, BMI was analyzed both as a dichotomized (top 20% versus bottom 20%) and a continuous trait. We found that a higher percentage of European ancestry was significantly correlated with lower BMI (rho = -0.042, P = 1.6x10(-7)). In the dichotomized analysis, we detected two loci on chromosome X as associated with increased African ancestry: the first at Xq25 (locus-specific LOD = 5.94; genome-wide score = 3.22; case-control Z = -3.94); and the second at Xq13.1 (locus-specific LOD = 2.22; case-control Z = -4.62). Quantitative analysis identified a third locus at 5q13.3 where higher BMI was highly significantly associated with greater European ancestry (locus-specific LOD = 6.27; genome-wide score = 3.46). Further mapping studies with dense sets of markers will be necessary to identify the alleles in these regions of chromosomes X and 5 that may be associated with variation in BMI.PLoS geneticsAdmixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X.PMC2679192U01 AR045614U01-AG027810U01 DK070657N01-HD-3-3175R21DK073482U01DK067207N01HC55019N01HC55018N01HC55016N01HC550151RL-1HL092550U01 AR45632U01 AR045580U01DK57292U01 AR045583U01DK070657N01 PC067010R01 AR035582R01 AR035583P01 CA017054R01 AG005394R01-ES-07084R01 AR035584R37 CA054281CA54281K01 DK083029R01-AR051124R01-HL-084107R01 AG005407R01 CA100598R01 CA063464R01 CA054281U01 AR45647N01-CO-12400U01 CA69417U01 AR045632R01 AR051124R01 CA77305N01-HC-55021N01-HC-55020N01HC95170U01 AG18197N01HC95171N01HC95172U01 HG004168N01-HC-55022T32 AG000181R01 CA074847CA63464RFA-CA-06-503K01 DK067207RL1 HL092550U01 AR45654R01 HL084107U01 AR45614N01-HC-55018AG05394N01-HC-55016U01 CA063464N01-HC-55015U01 DK057304U01-HG004168N01-HC-55019U01 AR045647U01DK57304U01 DK057292R21 DK073482N01HC55022CA 74847N01HC55021N01HC55020K01 DK083029-015T32AG000181-19K01DK067207AG05407CA 17054N01CO12400U01 AG027810AR35584U01 CA069417R01 CA063446AR35582AR35583U54-RR020278U01 AR45580U01 AR045654U54 RR020278U01 AG018197UL1 RR024140U01 AR45583Zmuda JMMiljkovic ITaylor HALeak TSXing CParekh RSBandera EVTandon AAkylbekova ELBrancati FLWilson JGBoerwinckle EHsueh WCArdlie KMeoni LAKao WHHaiman CAJohn EMAmbrosone CBJandorf LHUrsin GPawlikowska LOrwoll ESLi RCheng CYCoresh JPress MFFreedman MLReich DKlag MJFejerman LHenderson BEHarris TBPatterson NCiupak GLNalls MABernstein LfalseAdmixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X.The prevalence of obesity (body mass index (BMI) > or =30 kg/m(2)) is higher in African Americans than in European Americans, even after adjustment for socioeconomic factors, suggesting that genetic factors may explain some of the difference. To identify genetic loci influencing BMI, we carried out a pooled analysis of genome-wide admixture mapping scans in 15,280 African Americans from 14 epidemiologic studies. Samples were genotyped at a median of 1,411 ancestry-informative markers. After adjusting for age, sex, and study, BMI was analyzed both as a dichotomized (top 20% versus bottom 20%) and a continuous trait. We found that a higher percentage of European ancestry was significantly correlated with lower BMI (rho = -0.042, P = 1.6x10(-7)). In the dichotomized analysis, we detected two loci on chromosome X as associated with increased African ancestry: the first at Xq25 (locus-specific LOD = 5.94; genome-wide score = 3.22; case-control Z = -3.94); and the second at Xq13.1 (locus-specific LOD = 2.22; case-control Z = -4.62). Quantitative analysis identified a third locus at 5q13.3 where higher BMI was highly significantly associated with greater European ancestry (locus-specific LOD = 6.27; genome-wide score = 3.46). Further mapping studies with dense sets of markers will be necessary to identify the alleles in these regions of chromosomes X and 5 that may be associated with variation in BMI.2009-01-01T00:00:00Z2009 May2021-02-19T09:35:16Z2019-03-27T00:22:14ZS-EPMC26791921946188510.1371/journal.pgen.1000490