{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gurich N"],"funding":["NIGMS NIH HHS"],"pagination":["4372-82"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2698488"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["191(13)"],"pubmed_abstract":["The ExpR/Sin quorum-sensing system of the gram-negative soil bacterium Sinorhizobium meliloti plays an important role in the establishment of symbiosis with its host plant Medicago sativa. A mutant unable to produce autoinducer signal molecules (sinI) is deficient in its ability to invade the host, but paradoxically, a strain lacking the quorum-sensing transcriptional regulator ExpR is as efficient as the wild type. We compared the whole-genome expression profile of the wild-type strain with strains missing one of the quorum-sensing regulatory components to identify genes controlled by the ExpR/Sin system throughout the different phases of the bacterial growth cycle, as well as in planta. Our analyses revealed that ExpR is a highly versatile regulator with a unique ability to show differen"],"journal":["Journal of bacteriology"],"pubmed_title":["Role of quorum sensing in Sinorhizobium meliloti-Alfalfa symbiosis."],"pmcid":["PMC2698488"],"funding_grant_id":["R01 GM069925","1R01GM069925"],"pubmed_authors":["Gurich N","Gonzalez JE"],"additional_accession":[]},"is_claimable":false,"name":"Role of quorum sensing in Sinorhizobium meliloti-Alfalfa symbiosis.","description":"The ExpR/Sin quorum-sensing system of the gram-negative soil bacterium Sinorhizobium meliloti plays an important role in the establishment of symbiosis with its host plant Medicago sativa. A mutant unable to produce autoinducer signal molecules (sinI) is deficient in its ability to invade the host, but paradoxically, a strain lacking the quorum-sensing transcriptional regulator ExpR is as efficient as the wild type. We compared the whole-genome expression profile of the wild-type strain with strains missing one of the quorum-sensing regulatory components to identify genes controlled by the ExpR/Sin system throughout the different phases of the bacterial growth cycle, as well as in planta. Our analyses revealed that ExpR is a highly versatile regulator with a unique ability to show differen","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Jul","modification":"2025-04-26T00:34:54.637Z","creation":"2019-03-27T00:23:02Z"},"accession":"S-EPMC2698488","cross_references":{"pubmed":["19395488"],"doi":["10.1128/JB.00376-09","10.1128/jb.00376-09"]}}