{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Orozco G"],"funding":["Versus Arthritis","Medical Research Council","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["2693-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2701332"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(14)"],"pubmed_abstract":["The most consistent finding derived from the WTCCC GWAS for rheumatoid arthritis (RA) was association to a SNP at 6q23. We performed a fine-mapping of the region in order to search the 6q23 region for additional disease variants. 3962 RA patients and 3531 healthy controls were included in the study. We found 18 SNPs associated with RA. The SNP showing the strongest association was rs6920220 [P = 2.6 x 10(-6), OR (95% CI) 1.22 (1.13-1.33)]. The next most strongly associated SNP was rs13207033 [P = 0.0001, OR (95% CI) 0.86 (0.8-0.93)] which was perfectly correlated with rs10499194, a SNP previously associated with RA in a US/European series. Additionally, we found a number of new potential RA markers, including rs5029937, located in the intron 2 of TNFAIP3. Of the 18 associated SNPs, three p"],"journal":["Human molecular genetics"],"pubmed_title":["Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23."],"pmcid":["PMC2701332"],"funding_grant_id":["17552","G0000934","G0600329","18475","068545/Z/02","061858","NF-SI-0508-10299","068545","090532"],"pubmed_authors":["Stevens HE","Hordon L","Nimmo ER","Cardin NJ","Bentley D","McGuffin P","Taylor L","Mathew CG","Groves CJ","Lango H","Kirov G","Maqbool A","Xue M","Su Z","Ferrier IN","Easton D","Vannberg F","Walker M","Bax DE","Gordon-Smith K","Williamson R","Forbes A","Melsom R","Doherty S","Widden C","Cant B","McArdle WL","Zeggini E","Jolley JD","Jewell DP","Hill AV","Potter S","Winzer T","Young AH","Munroe PB","Seal S","Reece R","Sirugo G","Timpson NJ","Parkes M","Donnelly P","Potter C","Brown MJ","Stratton MR","Hinks A","Bradbury LA","Pickles D","Hocking L","Brown MA","Franklyn JA","Heard J","Quinn M","St Clair D","Knight AS","Dunger DB","McGonagle D","Green J","Holmans PA","Dominiczak A","Rayner NW","Green M","Grozeva D","Onipinla A","Lathrop GM","Corscadden D","Drummond H","Prescott NJ","Nunns C","Gill A","Taylor NC","Attwood AP","Fraser C","Jones RW","John SL","Firth J","Orozco G","Koch K","Inouye M","Worthington J","Pointon JJ","Hussey JM","YEAR consortium","Spencer CC","Burke B","Martin SG","Flynn E","Gwilliam R","Prowse CV","Evans D","Tremelling M","Samani NJ","Owen MJ","Sanderson J","Jones L","Robinson JI","Wallace C","Kwiatkowski DP","Bumpstead SJ","Walker NM","Stevens S","Barton A","Newport M","Withers D","Keenan AM","Henshaw K","Mohiuddin MK","Silman AJ","Dixon RJ","Mangino M","Huson G","Nam J","Perry JR","Morris AP","Elkin A","Hitman GA","Eyre S","Everson U","Ball SG","Gungadoo J","Morgan AW","Marchini JL","McCarthy MI","Yuldasheva N","Hider SL","Ring SM","Conway D","Rockett KA","Vukcevic D","Bredin F","Duncanson A","Emery P","Hinks AM","Adebajo A","Moskvina V","Sawcer SJ","Barbour J","Ke X","Satsangi J","Pereira-Gale J","Green EK","Martin P","Frayling TM","Martin M","Neville B","Meech E","Gilbert PD","Farrar C","Rashid LH","Lyons E","Hall AS","Connell J","Reid DM","Hattersley AT","Newhouse SJ","Pease C","Tobin MD","Helliwell P","Compston A","Thomas C","O'Donovan MC","Gough A","Whittaker P","Clayton DG","Deloukas P","Ferreira T","Iles MM","Lewis CM","Ouwehand WH","Lees CW","Burton PR","Thomson W","Walters GR","Kitcheman J","Farmer A","Bruce IN","Symmons DP","Elliott KS","Jallow M","Gough SC","Karim Z","Davison D","Weedon MN","Hunt SE","Balmforth AJ","Wellcome Trust Case Control Consortium","Lee KL","Cox S","Chaney A","Simmonds MJ","Fairclough A","Bowes J","Cardon LR","Braund PS","Todhunter CE","Ghori MJ","Hammond A","Bishop DT","Ahmad T","Goris A","Madden J","Donovan H","Hensor E","Lindgren CM","Brown C","Howie BN","Fisher SA","Boorman JP","Ban M","Mansfield JC","Marcano CA","Teo YY","Nikolov I","Gibbons LJ","Wordsworth P","Barrett JH","Keniry A","Webster J","Breen G","Barrett JC","Rahman N","McGinnis R","Jones IR","Farrall M","Hamshere ML","Rhys-Evans B","Todd JA","Freathy RM","Harvey A","Bejarano V","Heward JM","Widmer B","Leung HT","Harrison P","Ravindrarajah R","Jarrett S","Watkins NA","Padwell B","Caesar S","Pembrey M","Nutland S","Wilson AG","Collier DA","Thompson JR","Strachan DP","Downes K","King H","Onnie CM","Dobson R","King E","Morgan A","Caulfield M","Shields BM","Craddock N","Conaghan P","Isdale A","Steer S","Smith S","Hallgrimsdottir IB","Sigsworth L","Cummings FR"],"additional_accession":[]},"is_claimable":false,"name":"Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23.","description":"The most consistent finding derived from the WTCCC GWAS for rheumatoid arthritis (RA) was association to a SNP at 6q23. We performed a fine-mapping of the region in order to search the 6q23 region for additional disease variants. 3962 RA patients and 3531 healthy controls were included in the study. We found 18 SNPs associated with RA. The SNP showing the strongest association was rs6920220 [P = 2.6 x 10(-6), OR (95% CI) 1.22 (1.13-1.33)]. The next most strongly associated SNP was rs13207033 [P = 0.0001, OR (95% CI) 0.86 (0.8-0.93)] which was perfectly correlated with rs10499194, a SNP previously associated with RA in a US/European series. Additionally, we found a number of new potential RA markers, including rs5029937, located in the intron 2 of TNFAIP3. Of the 18 associated SNPs, three p","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Jul","modification":"2026-05-03T14:51:24.988Z","creation":"2019-03-27T00:23:10Z"},"accession":"S-EPMC2701332","cross_references":{"pubmed":["19417005"],"doi":["10.1093/hmg/ddp193"]}}