{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Walwyn W"],"funding":["NIDA NIH HHS"],"pagination":["134-43"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2701458"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["76(1)"],"pubmed_abstract":["Recombinant micro and delta opioid receptors expressed in cell lines can form heterodimers with distinctive properties and trafficking. However, a role for opioid receptor heterodimerization in neurons has yet to be identified. The inhibitory coupling of opioid receptors to voltage-dependent Ca(2+) channels (VDCCs) is a relatively inefficient process and therefore provides a sensitive assay of altered opioid receptor function and expression. We examined micro-receptor coupling to VDCCs in dorsal root ganglion neurons of delta(+/+), delta(+/-), and delta(-/-) mice. Neurons deficient in delta receptors exhibited reduced inhibition of VDCCs by morphine and [D-Ala(2),Phe(4),Gly(5)-ol]-enkephalin (DAMGO). An absence of delta receptors caused reduced efficacy of DAMGO without affecting potency. "],"journal":["Molecular pharmacology"],"pubmed_title":["Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons."],"pmcid":["PMC2701458"],"funding_grant_id":["DA05010","P50 DA005010","DA00484"],"pubmed_authors":["Walwyn W","Hales TG","Maga M","Evans CJ","John S"],"additional_accession":[]},"is_claimable":false,"name":"Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons.","description":"Recombinant micro and delta opioid receptors expressed in cell lines can form heterodimers with distinctive properties and trafficking. However, a role for opioid receptor heterodimerization in neurons has yet to be identified. The inhibitory coupling of opioid receptors to voltage-dependent Ca(2+) channels (VDCCs) is a relatively inefficient process and therefore provides a sensitive assay of altered opioid receptor function and expression. We examined micro-receptor coupling to VDCCs in dorsal root ganglion neurons of delta(+/+), delta(+/-), and delta(-/-) mice. Neurons deficient in delta receptors exhibited reduced inhibition of VDCCs by morphine and [D-Ala(2),Phe(4),Gly(5)-ol]-enkephalin (DAMGO). An absence of delta receptors caused reduced efficacy of DAMGO without affecting potency. ","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Jul","modification":"2026-05-03T14:51:34.303Z","creation":"2019-03-27T00:23:10Z"},"accession":"S-EPMC2701458","cross_references":{"pubmed":["19357247"],"doi":["10.1124/mol.109.055913"]}}