{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Roberts WK"],"funding":["NCRR NIH HHS","Howard Hughes Medical Institute","NCI NIH HHS"],"pagination":["2042-51"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2701858"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["119(7)"],"pubmed_abstract":["Paraneoplastic neurologic disorders (PNDs) offer an uncommon opportunity to study human tumor immunity and autoimmunity. In small cell lung cancer (SCLC), expression of the HuD neuronal antigen is thought to lead to immune recognition, suppression of tumor growth, and, in a subset of patients, triggering of the Hu paraneoplastic neurologic syndrome. Antigen-specific CTLs believed to contribute to disease pathophysiology were described 10 years ago in paraneoplastic cerebellar degeneration. Despite parallel efforts, similar cells have not been defined in Hu patients. Here, we have identified HuD-specific T cells in Hu patients and provided an explanation for why their detection has been elusive. Different Hu patients harbored 1 of 2 kinds of HuD-specific CD8+ T cells: classical IFN-gamma-pr"],"journal":["The Journal of clinical investigation"],"pubmed_title":["Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells."],"pmcid":["PMC2701858"],"funding_grant_id":["R01 CA85784","UL1 RR024143","R01 CA085784"],"pubmed_authors":["Deluca IJ","Fak J","Darnell RB","Thomas A","Roberts WK","Williams T","Posner JB","Buckley N","Dousmanis AG"],"additional_accession":[]},"is_claimable":false,"name":"Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells.","description":"Paraneoplastic neurologic disorders (PNDs) offer an uncommon opportunity to study human tumor immunity and autoimmunity. In small cell lung cancer (SCLC), expression of the HuD neuronal antigen is thought to lead to immune recognition, suppression of tumor growth, and, in a subset of patients, triggering of the Hu paraneoplastic neurologic syndrome. Antigen-specific CTLs believed to contribute to disease pathophysiology were described 10 years ago in paraneoplastic cerebellar degeneration. Despite parallel efforts, similar cells have not been defined in Hu patients. Here, we have identified HuD-specific T cells in Hu patients and provided an explanation for why their detection has been elusive. Different Hu patients harbored 1 of 2 kinds of HuD-specific CD8+ T cells: classical IFN-gamma-pr","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Jul","modification":"2026-03-16T16:24:38.524Z","creation":"2019-03-27T00:23:11Z"},"accession":"S-EPMC2701858","cross_references":{"pubmed":["19509467"],"doi":["10.1172/jci36131","10.1172/JCI36131"]}}