{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(7)"],"submitter":["Yu Y"],"pubmed_abstract":["Preimplantation genetic diagnosis (PGD), used in clinical practice, is offered to couples that may suffer from a monogenetic disorder, chromosome aneuploidy, or X-linked disease. However, blastomere biopsy, as an indispensable manipulation during the PGD procedure has not been assessed for its long term health implications. Using a mouse model, we investigated the effect of blastomere biopsy of in vitro cultured four-cell embryos on preimplantation development efficiency, postnatal growth, and physiological and behavioral activity compared with control, non-biopsied embryos. The mice generated after blastomere biopsy showed weight increase and some memory decline compared with the control group. Further protein expression profiles in adult brains were analyzed by a proteomics approach. A t"],"journal":["Molecular & cellular proteomics : MCP"],"pagination":["1490-500"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2709181"],"repository":["biostudies-literature"],"pubmed_title":["Evaluation of blastomere biopsy using a mouse model indicates the potential high risk of neurodegenerative disorders in the offspring."],"pmcid":["PMC2709181"],"pubmed_authors":["Lv Z","Wu J","Liu J","Fan Y","Zhao C","Zhou Q","Guo X","Zhou R","Chen L","Wang F","Zhu H","Zhou Z","Wang L","Xiao M","Sha J","Zhang Z","Chen W","Huo R","Lin M","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of blastomere biopsy using a mouse model indicates the potential high risk of neurodegenerative disorders in the offspring.","description":"Preimplantation genetic diagnosis (PGD), used in clinical practice, is offered to couples that may suffer from a monogenetic disorder, chromosome aneuploidy, or X-linked disease. However, blastomere biopsy, as an indispensable manipulation during the PGD procedure has not been assessed for its long term health implications. Using a mouse model, we investigated the effect of blastomere biopsy of in vitro cultured four-cell embryos on preimplantation development efficiency, postnatal growth, and physiological and behavioral activity compared with control, non-biopsied embryos. The mice generated after blastomere biopsy showed weight increase and some memory decline compared with the control group. Further protein expression profiles in adult brains were analyzed by a proteomics approach. A t","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Jul","modification":"2025-04-04T14:37:36.907Z","creation":"2019-06-06T21:31:06Z"},"accession":"S-EPMC2709181","cross_references":{"pubmed":["19279043"],"doi":["10.1074/mcp.M800273-MCP200","10.1074/mcp.m800273-mcp200"]}}