{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["185(4)"],"submitter":["Winderlich M"],"pubmed_abstract":["Vascular endothelial protein tyrosine phosphatase (VE-PTP) is an endothelial-specific receptor-type tyrosine phosphatase that associates with Tie-2 and VE-cadherin. VE-PTP gene disruption leads to embryonic lethality, vascular remodeling defects, and enlargement of vascular structures in extraembryonic tissues. We show here that antibodies against the extracellular part of VE-PTP mimic the effects of VE-PTP gene disruption exemplified by vessel enlargement in allantois explants. These effects require the presence of the angiopoietin receptor Tie-2. Analyzing the mechanism we found that anti-VE-PTP antibodies trigger endocytosis and selectively affect Tie-2-associated, but not VE-cadherin-associated VE-PTP. Dissociation of VE-PTP triggers the activation of Tie-2, leading to enhanced endothe"],"journal":["The Journal of cell biology"],"pagination":["657-71"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2711575"],"repository":["biostudies-literature"],"pubmed_title":["VE-PTP controls blood vessel development by balancing Tie-2 activity."],"pmcid":["PMC2711575"],"pubmed_authors":["Winderlich M","Vestweber D","Cagna G","Keller L","Kamenyeva O","Kiefer F","Broermann A","Deutsch U","Nottebaum AF"],"additional_accession":[]},"is_claimable":false,"name":"VE-PTP controls blood vessel development by balancing Tie-2 activity.","description":"Vascular endothelial protein tyrosine phosphatase (VE-PTP) is an endothelial-specific receptor-type tyrosine phosphatase that associates with Tie-2 and VE-cadherin. VE-PTP gene disruption leads to embryonic lethality, vascular remodeling defects, and enlargement of vascular structures in extraembryonic tissues. We show here that antibodies against the extracellular part of VE-PTP mimic the effects of VE-PTP gene disruption exemplified by vessel enlargement in allantois explants. These effects require the presence of the angiopoietin receptor Tie-2. Analyzing the mechanism we found that anti-VE-PTP antibodies trigger endocytosis and selectively affect Tie-2-associated, but not VE-cadherin-associated VE-PTP. Dissociation of VE-PTP triggers the activation of Tie-2, leading to enhanced endothe","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 May","modification":"2025-04-22T15:15:27.418Z","creation":"2019-06-06T21:31:29Z"},"accession":"S-EPMC2711575","cross_references":{"pubmed":["19451274"],"doi":["10.1083/jcb.200811159"]}}