biostudies-literatureSartor MANIEHS NIH HHSNHGRI NIH HHSNLM NIH HHS1139-46https://www.ebi.ac.uk/biostudies/studies/S-EPMC2717142biostudies-literatureUnknown117(7)<h4>Background</h4>The vertebrate aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates cellular responses to environmental polycyclic and halogenated compounds. The naive receptor is believed to reside in an inactive cytosolic complex that translocates to the nucleus and induces transcription of xenobiotic detoxification genes after activation by ligand.<h4>Objectives</h4>We conducted an integrative genomewide analysis of AHR gene targets in mouse hepatoma cells and determined whether AHR regulatory functions may take place in the absence of an exogenous ligand.<h4>Methods</h4>The network of AHR-binding targets in the mouse genome was mapped through a multipronged approach involving chromatin immunoprecipitation/chip and global gene expression signatureEnvironmental health perspectivesGenomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs.PMC2717142R01 ES006273R01 ES010807R21 LM009662T32 ES07250P30 ES06096P30 ES006096R01 ES10807R01 HG003749T32 ES007250R01 ES06273Liu XMarlowe JLMa CMedvedovic MFan YKaryala SPuga AHalbleib DReichard JFSartor MAWang YSchnekenburger MfalseGenomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs.<h4>Background</h4>The vertebrate aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates cellular responses to environmental polycyclic and halogenated compounds. The naive receptor is believed to reside in an inactive cytosolic complex that translocates to the nucleus and induces transcription of xenobiotic detoxification genes after activation by ligand.<h4>Objectives</h4>We conducted an integrative genomewide analysis of AHR gene targets in mouse hepatoma cells and determined whether AHR regulatory functions may take place in the absence of an exogenous ligand.<h4>Methods</h4>The network of AHR-binding targets in the mouse genome was mapped through a multipronged approach involving chromatin immunoprecipitation/chip and global gene expression signature2009-01-01T00:00:00Z2009 Jul2025-04-19T13:25:59.082Z2019-06-06T21:32:40ZS-EPMC27171421965492510.1289/ehp.0800485