{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yende S"],"funding":["NIGMS NIH HHS"],"pagination":["1242-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2720087"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["177(11)"],"pubmed_abstract":["<h4>Rationale</h4>Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown.<h4>Objectives</h4>To investigate whether persistent inflammation, defined as elevating circulating inflammatory markers at hospital discharge, is associated with subsequent outcomes.<h4>Methods</h4>Prospective cohort study at 28 sites.<h4>Measurements and main results</h4>We used standard criteria to define CAP and the National Death Index to determine all-cause and cause-specific 1-year mortality. At hospital discharge, 1,799 subjects (77.5%) were alive and vital signs had returned to normal in 1,512 (87%) subjects. The geometric means (+/-SD) for circulating IL-6 and IL-10 conce"],"journal":["American journal of respiratory and critical care medicine"],"pubmed_title":["Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis."],"pmcid":["PMC2720087"],"funding_grant_id":["R01 GM61992"],"pubmed_authors":["Welch RD","Knestaut L","Clark M","Siegel M","Weinberg J","Degutis LC","Solot J","Campbell TP","Shah K","Waddell L","Finegold D","Waselewsky D","Becich M","Fine JM","Holland S","Riordan R","Yuan X","Woods H","Morrow D","Pappu S","Nicholas J","Rosenbloom J","Pagano A","Wunderink RG","Christie J","Welch R","Heath R","He S","Fiehler PC","D'Angelo G","Martino M","Hewlett C","Jacobs B","Mostoufi M","Murcek MA","Saka G","Guzik LJ","Angus DC","Kessler L","Bucala R","Delbridge T","Jones C","Roberts MS","Weissfeld LA","Buono D","Riley P","Geyer S","Casey S","Weissfeld L","Gaudio F","Tang X","Rocker E","Kong L","Bernstein LH","Kruse J","St Clair C","Reynholds B","Auble TE","Nunnink K","Greenhouse D","Ergas S","Greer K","Patti M","Kellum JA","Joyce C","GenIMS Investigators","Basheda S","Sterling H","Papa R","Schaefer A","Wood KA","Hebda S","Moldovan J","Kreke J","Fink MP","Olson N","Laman D","Scinto L","Powell TA","Betcher K","Haddad R","Wang H","Yee E","Grogan A","Scherzer H","Bowman MV","Greenwald K","Strimlan CV","Singh J","Werdmann M","Darnley A","Dunne R","Yende S","Wells A","Arena V","Maggi G","Carter M","Young TL","Probst R","Cooper GF","Yang L","Flynn E","Feingold E","Tracey KJ","Null T","Graff LM","Wunderink R","Yealy DM","Hoteck T","Dooley C","Carius M","Martinez J","Krifcher C","Mandich LA","Gigler J","Friedman L","Bilicki K","Pinsky MR","McCaw M","Walshon J","Krichevsky A","McNamme M","Borochovitz D","Grant R","Rivers E","Morris A","Ferrell R","Kristan W","Jatlow P","Nair S","Chaudhry R","Castor E","Hufnagel M","MacLeod B","Rolniak S","Shaufl A","Wolf S","Hewitt L","Gorsha N","Visweswaran S","Rahim M","Khasnabis S","Fine J","Kuzma J","Campbell L","Anderson J","Naples M","Bennett N","Delude RL","Belden C","Furman A","Kumar RK","Provenzano M","Fine MJ","DeLuca C"],"additional_accession":[]},"is_claimable":false,"name":"Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis.","description":"<h4>Rationale</h4>Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown.<h4>Objectives</h4>To investigate whether persistent inflammation, defined as elevating circulating inflammatory markers at hospital discharge, is associated with subsequent outcomes.<h4>Methods</h4>Prospective cohort study at 28 sites.<h4>Measurements and main results</h4>We used standard criteria to define CAP and the National Death Index to determine all-cause and cause-specific 1-year mortality. At hospital discharge, 1,799 subjects (77.5%) were alive and vital signs had returned to normal in 1,512 (87%) subjects. The geometric means (+/-SD) for circulating IL-6 and IL-10 conce","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Jun","modification":"2025-04-22T21:51:33.092Z","creation":"2019-03-27T00:23:57Z"},"accession":"S-EPMC2720087","cross_references":{"pubmed":["18369199"],"doi":["10.1164/rccm.200712-1777OC","10.1164/rccm.200712-1777oc"]}}