biostudies-literatureYende SNIGMS NIH HHS1242-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC2720087biostudies-literatureUnknown177(11)<h4>Rationale</h4>Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown.<h4>Objectives</h4>To investigate whether persistent inflammation, defined as elevating circulating inflammatory markers at hospital discharge, is associated with subsequent outcomes.<h4>Methods</h4>Prospective cohort study at 28 sites.<h4>Measurements and main results</h4>We used standard criteria to define CAP and the National Death Index to determine all-cause and cause-specific 1-year mortality. At hospital discharge, 1,799 subjects (77.5%) were alive and vital signs had returned to normal in 1,512 (87%) subjects. The geometric means (+/-SD) for circulating IL-6 and IL-10 conceAmerican journal of respiratory and critical care medicineInflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis.PMC2720087R01 GM61992Welch RDKnestaut LClark MSiegel MWeinberg JDegutis LCSolot JCampbell TPShah KWaddell LFinegold DWaselewsky DBecich MFine JMHolland SRiordan RYuan XWoods HMorrow DPappu SNicholas JRosenbloom JPagano AWunderink RGChristie JWelch RHeath RHe SFiehler PCD'Angelo GMartino MHewlett CJacobs BMostoufi MMurcek MASaka GGuzik LJAngus DCKessler LBucala RDelbridge TJones CRoberts MSWeissfeld LABuono DRiley PGeyer SCasey SWeissfeld LGaudio FTang XRocker EKong LBernstein LHKruse JSt Clair CReynholds BAuble TENunnink KGreenhouse DErgas SGreer KPatti MKellum JAJoyce CGenIMS InvestigatorsBasheda SSterling HPapa RSchaefer AWood KAHebda SMoldovan JKreke JFink MPOlson NLaman DScinto LPowell TABetcher KHaddad RWang HYee EGrogan AScherzer HBowman MVGreenwald KStrimlan CVSingh JWerdmann MDarnley ADunne RYende SWells AArena VMaggi GCarter MYoung TLProbst RCooper GFYang LFlynn EFeingold ETracey KJNull TGraff LMWunderink RYealy DMHoteck TDooley CCarius MMartinez JKrifcher CMandich LAGigler JFriedman LBilicki KPinsky MRMcCaw MWalshon JKrichevsky AMcNamme MBorochovitz DGrant RRivers EMorris AFerrell RKristan WJatlow PNair SChaudhry RCastor EHufnagel MMacLeod BRolniak SShaufl AWolf SHewitt LGorsha NVisweswaran SRahim MKhasnabis SFine JKuzma JCampbell LAnderson JNaples MBennett NDelude RLBelden CFurman AKumar RKProvenzano MFine MJDeLuca CfalseInflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis.<h4>Rationale</h4>Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown.<h4>Objectives</h4>To investigate whether persistent inflammation, defined as elevating circulating inflammatory markers at hospital discharge, is associated with subsequent outcomes.<h4>Methods</h4>Prospective cohort study at 28 sites.<h4>Measurements and main results</h4>We used standard criteria to define CAP and the National Death Index to determine all-cause and cause-specific 1-year mortality. At hospital discharge, 1,799 subjects (77.5%) were alive and vital signs had returned to normal in 1,512 (87%) subjects. The geometric means (+/-SD) for circulating IL-6 and IL-10 conce2008-01-01T00:00:00Z2008 Jun2025-04-22T21:51:33.092Z2019-03-27T00:23:57ZS-EPMC27200871836919910.1164/rccm.200712-1777OC10.1164/rccm.200712-1777oc