{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma H"],"funding":["Medical Research Council"],"pagination":["12980-5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2722359"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["106(31)"],"pubmed_abstract":["In 1999, the population of Vancouver Island, Canada, began to experience an outbreak of a fatal fungal disease caused by a highly virulent lineage of Cryptococcus gattii. This organism has recently spread to the Canadian mainland and Pacific Northwest, but the molecular cause of the outbreak remains unknown. Here we show that the Vancouver Island outbreak (VIO) isolates have dramatically increased their ability to replicate within macrophages of the mammalian immune system in comparison with other C. gattii strains. We further demonstrate that such enhanced intracellular parasitism is directly linked to virulence in a murine model of cryptococcosis, suggesting that this phenotype may be the cause of the outbreak. Finally, microarray studies on 24 C. gattii strains reveals that the hypervir"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation."],"pmcid":["PMC2722359"],"funding_grant_id":["G0601171"],"pubmed_authors":["Falk R","Polacheck I","Ma H","Boekhout T","Hagen F","Johnston SA","Stekel DJ","Sionov E","May RC"],"additional_accession":[]},"is_claimable":false,"name":"The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation.","description":"In 1999, the population of Vancouver Island, Canada, began to experience an outbreak of a fatal fungal disease caused by a highly virulent lineage of Cryptococcus gattii. This organism has recently spread to the Canadian mainland and Pacific Northwest, but the molecular cause of the outbreak remains unknown. Here we show that the Vancouver Island outbreak (VIO) isolates have dramatically increased their ability to replicate within macrophages of the mammalian immune system in comparison with other C. gattii strains. We further demonstrate that such enhanced intracellular parasitism is directly linked to virulence in a murine model of cryptococcosis, suggesting that this phenotype may be the cause of the outbreak. Finally, microarray studies on 24 C. gattii strains reveals that the hypervir","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Aug","modification":"2026-05-03T16:48:45.747Z","creation":"2026-04-07T19:25:03.756Z"},"accession":"S-EPMC2722359","cross_references":{"pubmed":["19651610"],"doi":["10.1073/pnas.0902963106"]}}