{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Benzo R"],"funding":["NHLBI NIH HHS","NCI NIH HHS"],"pagination":["239-46"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2724716"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["180(3)"],"pubmed_abstract":["<h4>Rationale</h4>In studies that address health-related quality of life (QoL) and survival, subjects who die are usually censored from QoL assessments. This practice tends to inflate the apparent benefits of interventions with a high risk of mortality. Assessing a composite QoL-death outcome is a potential solution to this problem.<h4>Objectives</h4>To determine the effect of lung volume reduction surgery (LVRS) on a composite endpoint consisting of the occurrence of death or a clinically meaningful decline in QoL defined as an increase of at least eight points in the St. George's Respiratory Questionnaire total score from the National Emphysema Treatment Trial.<h4>Methods</h4>In patients with chronic obstructive pulmonary disease and emphysema randomized to receive medical treatment (n ="],"journal":["American journal of respiratory and critical care medicine"],"pubmed_title":["Integrating health status and survival data: the palliative effect of lung volume reduction surgery."],"pmcid":["PMC2724716"],"funding_grant_id":["N01HR76115","N01HR76104","N01HR76103","N01HR76114","N01HR76106","N01HR76105","N01HR76116","N01HR76111","N01HR76110","N01HR76102","N01HR76113","N01HR76101","N01HR76112","1K23CA106544","K23 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K","Kupferberg D","Hale K","Lorenzon M","Kupferberg C","Kreizenbeck K","Brister N","Body S","O'Connell R","Meziane M","Anable K","Bartels M","DeMets D","Krichman A","Fessler H","Bendel S","Coleman RE","Friedman P","Delsing A","Drake J","King M","King K","Janice Willey JW","Strollo D","Aughenbaugh G","Utz J","Wahl P","Andrist D","Al-Amin A","Shiau M","Deschamps C","Berkowitz SM","Pfeffer J","Kwak C","Campbell K","Nguyen C","Brown M","Kopp T","Cherniack R","Fuller J"],"additional_accession":[]},"is_claimable":false,"name":"Integrating health status and survival data: the palliative effect of lung volume reduction surgery.","description":"<h4>Rationale</h4>In studies that address health-related quality of life (QoL) and survival, subjects who die are usually censored from QoL assessments. This practice tends to inflate the apparent benefits of interventions with a high risk of mortality. Assessing a composite QoL-death outcome is a potential solution to this problem.<h4>Objectives</h4>To determine the effect of lung volume reduction surgery (LVRS) on a composite endpoint consisting of the occurrence of death or a clinically meaningful decline in QoL defined as an increase of at least eight points in the St. George's Respiratory Questionnaire total score from the National Emphysema Treatment Trial.<h4>Methods</h4>In patients with chronic obstructive pulmonary disease and emphysema randomized to receive medical treatment (n =","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Aug","modification":"2025-04-22T11:15:50.502Z","creation":"2019-03-27T00:24:09Z"},"accession":"S-EPMC2724716","cross_references":{"pubmed":["19483114"],"doi":["10.1164/rccm.200809-1383OC","10.1164/rccm.200809-1383oc"]}}