biostudies-literatureBenzo RNHLBI NIH HHSNCI NIH HHS239-46https://www.ebi.ac.uk/biostudies/studies/S-EPMC2724716biostudies-literatureUnknown180(3)<h4>Rationale</h4>In studies that address health-related quality of life (QoL) and survival, subjects who die are usually censored from QoL assessments. This practice tends to inflate the apparent benefits of interventions with a high risk of mortality. Assessing a composite QoL-death outcome is a potential solution to this problem.<h4>Objectives</h4>To determine the effect of lung volume reduction surgery (LVRS) on a composite endpoint consisting of the occurrence of death or a clinically meaningful decline in QoL defined as an increase of at least eight points in the St. George's Respiratory Questionnaire total score from the National Emphysema Treatment Trial.<h4>Methods</h4>In patients with chronic obstructive pulmonary disease and emphysema randomized to receive medical treatment (n =American journal of respiratory and critical care medicineIntegrating health status and survival data: the palliative effect of lung volume reduction surgery.PMC2724716N01HR76115N01HR76104N01HR76103N01HR76114N01HR76106N01HR76105N01HR76116N01HR76111N01HR76110N01HR76102N01HR76113N01HR76101N01HR761121K23CA106544K23 CA106544N01HR76119N01HR76108N01HR76118N01HR76107N01HR76109Young CHooper SSexton JBoitano LMoskowitz IMullan BDurr TAyres GCordova FRodarte JChang CCBenedict BMcAdams HVilotijevic DDweik RLawlor BGerber RRoessler LNETT Research GroupWaldhausen JAHowe JRussell RGilmartin MKazerooni ERussell WWhite KBoiselle PNewell JLipson DQi SReardon MStanford WElliot BRoss PJulien PGillespie DMiller DRamirez CWhite CMiller CValentina Yegyan VYMcKenna REdell EShroyer ALEdmonds VReilly JO'Shea MWoodcock BMarglin SSimcox RDiMango AHarrell JMiller WJoyner MZisman DNancy Kurokawa NKSnyder MKnieper VHicks DMaurer JRamsey SHaddad JGinsburg MMcSweeny AJPalevsky HGrichnik KMantinaos MCarter JPlankeel JSaunders DGilbert TVance GMcDowell PHoover EBria WWagner JLamb JWiener-Kronish JKotler-Klein LMartinez FSullivan SJohnson JAlavi AJhingran SChamberlain WHyatt RWeir CFlaherty KSullivan EReeves-Viets JMidthun DStoller JPropst JChatziioannou SHartman TBenzo RDeCamp MStolar CLimberg TTino GBerkmen YTravaline JMendez JRossoff LBelt PWrona CTonascia JDuffy SMeli YCulver BFox PGuo JMoy MRittinger DKrasna MThomashow BMinai OLevine CNaunheim KOrens JDeMercado GWalter JIbrahim AYounes MEdgar MWinner KHowlader NDubose KAtul Mehta AMHandelsman HMieras KKeller CLevine REtzioni RBaldwin JCagle PPeterson SDeVilliers PFrese SMeinert JNorris ABradt KChristensen PSchroeder TNowakowski DSnedeker SMcLennan GOpelman SMartay KSugarbaker DKaiser LGillespy TKaplan RTapson VAlcorn TWood BTsang DJellen PHubmayr RFrankville DWood DBartling SSoltoff CMilburn-Barnes MOjo TWise RSieren JBaker EGreene DSharafkhaneh ACook-Granroth JTeague RShearer SWilliams ODGeaga CSisson TMcCreight PLockhart DSteele MDiaz PMets BHibbit ABattaglia NCanterbury JSax SHammel BRies ACarino TOxorn DAukberg SWard PMottram CKraenzler EBenditt JBozzarello BASheingold SRuppel GHarle JJennifer Minkoff-Rau JMLacomis JYusen RCarney KKhan ARittinger MSheaffer HSmith JSmith PCrouch RZamora MSmith MChapman JKotloff RPiantadosi SSiegelman SGerhardt MStone-Wynne JWilliams KWeinmann GWhalen-Price JDeshler JStavrolakes KHarpole DTaylor KFerguson MFoster GLMohsenifar ZCutler JBees TKatz MHartigan PMoskowitz AJStafford-Smith MChin JGarrett JBlackford ABan Natta MO'Donovan PLynch DFurukawa SLann RDo SPapatheofanis FJPoole LOsterloh JGeorge ELubell SMagliocca MOwens KMeldrum CCriner GSassi-Dambron DGeyman LFarrell MHClancy CMake BScharf SGolden SSilfies LDodge JDibbern PQuaife RShirey SZaremba LBauldoff GFishman APYip CPearson GBarnard PSykes AMEllisor MMcKeon KKalra SBernard GKirsch KDonithan MKuzma AMHarms GJenson NKazanjian PBrogan FGodwin DGill PChwalik CColvin RSimonelli PHoffman RLivingston HMcVearry KLewis MSteiger MAbel MOfficer TEdelman JMarlow SKapelanski DBerkoski PFuhlbrigge AFendrick AMJahn AKaplan RMFahs MCFuhrman CRysso PSikora CLautensack KNizami IJensen ECollison BRising PAtwell DMahler DRaymond CConejo-Gonzales KPathak DHoffman EDempsey MLHoffman JHearn CWitt CJackson REspada RHart JQuint LAronchick JAlvarez FBowdle AApostolakis JCollins KMartin UHudson CD'Alonzo GBorosh SWilson LJacobson FRicketts JWilson OSchartel SEmery CWeeks MO'Brien GButanda RGefter WKeenan RMeyers JWurster AGay SChan LKachulis BHanson KMcCarthy KJudd Gurney JGHanson LLuketich JFanning CChong ABarnette RPiker CFrantz RChiang YPSciurba FIannettoni MFormanek VKleinhenz MEArcasoy SClark SDonahoe MLee STorres NWheeler CHood ESchilz RKiley JChatila WMacIntyre NEdwards BShade DSchwartz JSKarsell PSciurba FCMartinez FJHunsaker APomerantz MSwanson SDaniele RSwensen SFernandez EDavis RDHansen-Flaschen JSilver KAustin JSlivka WAllen MBosco LKleiman NBiring MKeresztury MNorten JSimon BWu MRinaldo-Gallo SSternberg AReinhardt JFollmann DSimon TToshima MCraemer STrue MCarlos MBerry KKupferberg DHale KLorenzon MKupferberg CKreizenbeck KBrister NBody SO'Connell RMeziane MAnable KBartels MDeMets DKrichman AFessler HBendel SColeman REFriedman PDelsing ADrake JKing MKing KJanice Willey JWStrollo DAughenbaugh GUtz JWahl PAndrist DAl-Amin AShiau MDeschamps CBerkowitz SMPfeffer JKwak CCampbell KNguyen CBrown MKopp TCherniack RFuller JfalseIntegrating health status and survival data: the palliative effect of lung volume reduction surgery.<h4>Rationale</h4>In studies that address health-related quality of life (QoL) and survival, subjects who die are usually censored from QoL assessments. This practice tends to inflate the apparent benefits of interventions with a high risk of mortality. Assessing a composite QoL-death outcome is a potential solution to this problem.<h4>Objectives</h4>To determine the effect of lung volume reduction surgery (LVRS) on a composite endpoint consisting of the occurrence of death or a clinically meaningful decline in QoL defined as an increase of at least eight points in the St. George's Respiratory Questionnaire total score from the National Emphysema Treatment Trial.<h4>Methods</h4>In patients with chronic obstructive pulmonary disease and emphysema randomized to receive medical treatment (n =2009-01-01T00:00:00Z2009 Aug2025-04-22T11:15:50.502Z2019-03-27T00:24:09ZS-EPMC27247161948311410.1164/rccm.200809-1383OC10.1164/rccm.200809-1383oc