{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Crickmore MA"],"funding":["NIDDK NIH HHS","NIGMS NIH HHS"],"pagination":["e1000633"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2726431"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(9)"],"pubmed_abstract":["For gene products that must be present in cells at defined concentrations, expression levels must be tightly controlled to ensure robustness against environmental, genetic, and developmental noise. By studying the regulation of the concentration-sensitive Drosophila melanogaster Hox gene Ultrabithorax (Ubx), we found that Ubx enhancer activities respond to both increases in Ubx levels and genetic background. Large, transient increases in Ubx levels are capable of silencing all enhancer input into Ubx transcription, resulting in the complete silencing of this gene. Small increases in Ubx levels, brought about by duplications of the Ubx locus, cause sporadic silencing of subsets of Ubx enhancers. Ubx enhancer silencing can also be induced by outcrossing laboratory stocks to D. melanogaster s"],"journal":["PLoS genetics"],"pubmed_title":["Regulation of Ubx expression by epigenetic enhancer silencing in response to Ubx levels and genetic variation."],"pmcid":["PMC2726431"],"funding_grant_id":["GM054510","R01 GM058575","GM058575","DK07328","T32 GM008798","R01 GM054510","GM008798","T32 DK007328"],"pubmed_authors":["Mann RS","Crickmore MA","Ranade V"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of Ubx expression by epigenetic enhancer silencing in response to Ubx levels and genetic variation.","description":"For gene products that must be present in cells at defined concentrations, expression levels must be tightly controlled to ensure robustness against environmental, genetic, and developmental noise. By studying the regulation of the concentration-sensitive Drosophila melanogaster Hox gene Ultrabithorax (Ubx), we found that Ubx enhancer activities respond to both increases in Ubx levels and genetic background. Large, transient increases in Ubx levels are capable of silencing all enhancer input into Ubx transcription, resulting in the complete silencing of this gene. Small increases in Ubx levels, brought about by duplications of the Ubx locus, cause sporadic silencing of subsets of Ubx enhancers. Ubx enhancer silencing can also be induced by outcrossing laboratory stocks to D. melanogaster s","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Sep","modification":"2025-05-18T13:33:47.466Z","creation":"2025-05-18T13:33:47.466Z"},"accession":"S-EPMC2726431","cross_references":{"pubmed":["19730678"],"doi":["10.1371/journal.pgen.1000633"]}}