{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["94(8)"],"submitter":["Lai EW"],"funding":["Intramural NIH HHS"],"pubmed_abstract":["<h4>Context</h4>Pheochromocytomas and paragangliomas are rare catecholamine-secreting neuroendocrine tumors arising from the adrenal medulla and sympathetic tissues. When complete surgical resection is not an option, the treatment of pheochromocytoma is limited.<h4>Objective</h4>The objective of the study was to identify and characterize overexpression of IL-13 receptor-alpha2 (IL-13Ralpha2) gene expression in human and murine tumors and verify xenograft mouse pheochromocytoma cell (MPC)-derived tumor's response to a selective cytotoxin.<h4>Design/setting/patients</h4>Expression of IL-13Ralpha2 was evaluated in a panel of 25 human pheochromocytoma clinical samples by RT-PCR and eight MPC tumors by indirect immunofluorescence assay and RT-PCR.<h4>Intervention</h4>The function of IL-13Ralpha"],"journal":["The Journal of clinical endocrinology and metabolism"],"pagination":["2952-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2730867"],"repository":["biostudies-literature"],"pubmed_title":["Overexpression of interleukin-13 receptor-alpha2 in neuroendocrine malignant pheochromocytoma: a novel target for receptor directed anti-cancer therapy."],"pmcid":["PMC2730867"],"pubmed_authors":["Leland P","Joshi BH","Fujisawa T","Lai EW","Elkahloun AG","de Krijger RR","Lubensky IA","Puri RK","Martiniova L","Morris JC","Pacak K","Dogra R"],"additional_accession":[]},"is_claimable":false,"name":"Overexpression of interleukin-13 receptor-alpha2 in neuroendocrine malignant pheochromocytoma: a novel target for receptor directed anti-cancer therapy.","description":"<h4>Context</h4>Pheochromocytomas and paragangliomas are rare catecholamine-secreting neuroendocrine tumors arising from the adrenal medulla and sympathetic tissues. When complete surgical resection is not an option, the treatment of pheochromocytoma is limited.<h4>Objective</h4>The objective of the study was to identify and characterize overexpression of IL-13 receptor-alpha2 (IL-13Ralpha2) gene expression in human and murine tumors and verify xenograft mouse pheochromocytoma cell (MPC)-derived tumor's response to a selective cytotoxin.<h4>Design/setting/patients</h4>Expression of IL-13Ralpha2 was evaluated in a panel of 25 human pheochromocytoma clinical samples by RT-PCR and eight MPC tumors by indirect immunofluorescence assay and RT-PCR.<h4>Intervention</h4>The function of IL-13Ralpha","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Aug","modification":"2025-04-05T11:53:17.707Z","creation":"2019-03-26T23:59:14Z"},"accession":"S-EPMC2730867","cross_references":{"pubmed":["19491224"],"doi":["10.1210/jc.2009-0309"]}}