biostudies-literatureUnknown94(8)Lai EWIntramural NIH HHS<h4>Context</h4>Pheochromocytomas and paragangliomas are rare catecholamine-secreting neuroendocrine tumors arising from the adrenal medulla and sympathetic tissues. When complete surgical resection is not an option, the treatment of pheochromocytoma is limited.<h4>Objective</h4>The objective of the study was to identify and characterize overexpression of IL-13 receptor-alpha2 (IL-13Ralpha2) gene expression in human and murine tumors and verify xenograft mouse pheochromocytoma cell (MPC)-derived tumor's response to a selective cytotoxin.<h4>Design/setting/patients</h4>Expression of IL-13Ralpha2 was evaluated in a panel of 25 human pheochromocytoma clinical samples by RT-PCR and eight MPC tumors by indirect immunofluorescence assay and RT-PCR.<h4>Intervention</h4>The function of IL-13RalphaThe Journal of clinical endocrinology and metabolism2952-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC2730867biostudies-literatureOverexpression of interleukin-13 receptor-alpha2 in neuroendocrine malignant pheochromocytoma: a novel target for receptor directed anti-cancer therapy.PMC2730867Leland PJoshi BHFujisawa TLai EWElkahloun AGde Krijger RRLubensky IAPuri RKMartiniova LMorris JCPacak KDogra RfalseOverexpression of interleukin-13 receptor-alpha2 in neuroendocrine malignant pheochromocytoma: a novel target for receptor directed anti-cancer therapy.<h4>Context</h4>Pheochromocytomas and paragangliomas are rare catecholamine-secreting neuroendocrine tumors arising from the adrenal medulla and sympathetic tissues. When complete surgical resection is not an option, the treatment of pheochromocytoma is limited.<h4>Objective</h4>The objective of the study was to identify and characterize overexpression of IL-13 receptor-alpha2 (IL-13Ralpha2) gene expression in human and murine tumors and verify xenograft mouse pheochromocytoma cell (MPC)-derived tumor's response to a selective cytotoxin.<h4>Design/setting/patients</h4>Expression of IL-13Ralpha2 was evaluated in a panel of 25 human pheochromocytoma clinical samples by RT-PCR and eight MPC tumors by indirect immunofluorescence assay and RT-PCR.<h4>Intervention</h4>The function of IL-13Ralpha2009-01-01T00:00:00Z2009 Aug2025-04-05T11:53:17.707Z2019-03-26T23:59:14ZS-EPMC27308671949122410.1210/jc.2009-0309