{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mans JJ"],"funding":["NIDCR NIH HHS"],"pagination":["380"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2736203"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["<h4>Background</h4>The human microflora is known to be extremely complex, yet most pathogenesis research is conducted in mono-species models of infection. Consequently, it remains unclear whether the level of complexity of a host's indigenous flora can affect the virulence potential of pathogenic species. Furthermore, it remains unclear whether the colonization by commensal species affects a host cell's response to pathogenic species beyond the direct physical saturation of surface receptors, the sequestration of nutrients, the modulation of the physico-chemical environment in the oral cavity, or the production of bacteriocins. Using oral epithelial cells as a model, we hypothesized that the virulence of pathogenic species may vary depending on the complexity of the flora that interacts wi"],"journal":["BMC genomics"],"pubmed_title":["The degree of microbiome complexity influences the epithelial response to infection."],"pmcid":["PMC2736203"],"funding_grant_id":["R01 DE016715","R01 DE11111","R01 DE011111","T32 DE007200","DE07200","R01 DE16715"],"pubmed_authors":["Baker HV","von Lackum K","Dorsey C","Wallet SM","Handfield M","Willis S","Lamont RJ","Mans JJ"],"additional_accession":[]},"is_claimable":false,"name":"The degree of microbiome complexity influences the epithelial response to infection.","description":"<h4>Background</h4>The human microflora is known to be extremely complex, yet most pathogenesis research is conducted in mono-species models of infection. Consequently, it remains unclear whether the level of complexity of a host's indigenous flora can affect the virulence potential of pathogenic species. Furthermore, it remains unclear whether the colonization by commensal species affects a host cell's response to pathogenic species beyond the direct physical saturation of surface receptors, the sequestration of nutrients, the modulation of the physico-chemical environment in the oral cavity, or the production of bacteriocins. Using oral epithelial cells as a model, we hypothesized that the virulence of pathogenic species may vary depending on the complexity of the flora that interacts wi","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Aug","modification":"2026-05-03T16:56:08.958Z","creation":"2026-04-07T19:26:34.135Z"},"accession":"S-EPMC2736203","cross_references":{"pubmed":["19689803"],"doi":["10.1186/1471-2164-10-380"]}}