{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["He G"],"funding":["NIGMS NIH HHS"],"pagination":["12088-90"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2742410"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["131(34)"],"pubmed_abstract":["In this communication, we show that peptide nucleic acids (PNAs) with lengths of 15-20 nucleotides, when preorganized into a right-handed helix, can invade mixed-sequence double-helical B-form DNA (B-DNA). Strand invasion occurs in a highly sequence-specific manner through direct Watson-Crick base pairing. Unlike the previously developed double-duplex invasion strategy, which requires simultaneous binding of two strands of pseudocomplementary PNAs to DNA, only a single strand of gammaPNA is required for invasion in this case, and no nucleobase substitution is needed."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Strand invasion of extended, mixed-sequence B-DNA by gammaPNAs."],"pmcid":["PMC2742410"],"funding_grant_id":["R01 GM077261","R01 GM077261-04","GM076251"],"pubmed_authors":["Rapireddy S","Ly DH","He G","Sahu B","Bahal R"],"additional_accession":[]},"is_claimable":false,"name":"Strand invasion of extended, mixed-sequence B-DNA by gammaPNAs.","description":"In this communication, we show that peptide nucleic acids (PNAs) with lengths of 15-20 nucleotides, when preorganized into a right-handed helix, can invade mixed-sequence double-helical B-form DNA (B-DNA). Strand invasion occurs in a highly sequence-specific manner through direct Watson-Crick base pairing. Unlike the previously developed double-duplex invasion strategy, which requires simultaneous binding of two strands of pseudocomplementary PNAs to DNA, only a single strand of gammaPNA is required for invasion in this case, and no nucleobase substitution is needed.","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Sep","modification":"2025-04-20T01:51:50.65Z","creation":"2019-03-27T00:24:52Z"},"accession":"S-EPMC2742410","cross_references":{"pubmed":["19663424"],"doi":["10.1021/ja900228j"]}}