{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["284(31)"],"submitter":["Li D"],"pubmed_abstract":["LFA-1 regulates T cell activation and signal transduction through the immunological synapse. T cell receptor (TCR) stimulation rapidly activates LFA-1, which provides unique LFA-1-dependent signals to promote T cell activation. However, the detailed molecular pathways that regulate these processes and the precise mechanism by which LFA-1 contributes to TCR activation remain unclear. We found LFA-1 directly participates in Erk1/2 signaling upon TCR stimulation in CD8+ T cells. The presence of LFA-1, not ligand binding, is required for the TCR-mediated Erk1/2 signal pathway. LFA-1-deficient T cells have defects in sustained Erk1/2 signaling and TCR/CD3 clustering, which subsequently prevents MTOC reorientation, cell cycle progression, and mitosis. LFA-1 regulates the TCR-mediated Erk1/2 sign"],"journal":["The Journal of biological chemistry"],"pagination":["21001-10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2742865"],"repository":["biostudies-literature"],"pubmed_title":["LFA-1 regulates CD8+ T cell activation via T cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathways."],"pmcid":["PMC2742865"],"pubmed_authors":["Molldrem JJ","Ma Q","Li D"],"additional_accession":[]},"is_claimable":false,"name":"LFA-1 regulates CD8+ T cell activation via T cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathways.","description":"LFA-1 regulates T cell activation and signal transduction through the immunological synapse. T cell receptor (TCR) stimulation rapidly activates LFA-1, which provides unique LFA-1-dependent signals to promote T cell activation. However, the detailed molecular pathways that regulate these processes and the precise mechanism by which LFA-1 contributes to TCR activation remain unclear. We found LFA-1 directly participates in Erk1/2 signaling upon TCR stimulation in CD8+ T cells. The presence of LFA-1, not ligand binding, is required for the TCR-mediated Erk1/2 signal pathway. LFA-1-deficient T cells have defects in sustained Erk1/2 signaling and TCR/CD3 clustering, which subsequently prevents MTOC reorientation, cell cycle progression, and mitosis. LFA-1 regulates the TCR-mediated Erk1/2 sign","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Jul","modification":"2026-03-16T16:55:28.067Z","creation":"2019-03-27T00:24:54Z"},"accession":"S-EPMC2742865","cross_references":{"pubmed":["19483086"],"doi":["10.1074/jbc.m109.002865","10.1074/jbc.M109.002865"]}}