{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Carvalho GB"],"funding":["NIA NIH HHS","NIDDK NIH HHS","Medical Research Council"],"pagination":["813-5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2745347"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(11)"],"pubmed_abstract":["Dietary restriction extends the lifespan of numerous, evolutionarily diverse species. In D. melanogaster, a prominent model for research on the interaction between nutrition and longevity, dietary restriction is typically based on medium dilution, with possible compensatory ingestion commonly being neglected. Possible problems with this approach are revealed by using a method for direct monitoring of D. melanogaster feeding behavior. This demonstrates that dietary restriction elicits robust compensatory changes in food consumption. As a result, the effect of medium dilution is overestimated and, in certain cases, even fully compensated for. Our results strongly indicate that feeding behavior and nutritional composition act concertedly to determine fly lifespan. Feeding behavior thus emerge"],"journal":["Nature methods"],"pubmed_title":["Compensatory ingestion upon dietary restriction in Drosophila melanogaster."],"pmcid":["PMC2745347"],"funding_grant_id":["AG16630","R21 AG028241-01","R21 AG028241-02","G9900989","R21 AG028241","DK070154","R01 AG024366-02","R01 AG024366-01","AG24366","RL1 AG032113","R01 AG024366-02S1","R01 AG024366-03"],"pubmed_authors":["Carvalho GB","Benzer S","Kapahi P"],"additional_accession":[]},"is_claimable":false,"name":"Compensatory ingestion upon dietary restriction in Drosophila melanogaster.","description":"Dietary restriction extends the lifespan of numerous, evolutionarily diverse species. In D. melanogaster, a prominent model for research on the interaction between nutrition and longevity, dietary restriction is typically based on medium dilution, with possible compensatory ingestion commonly being neglected. Possible problems with this approach are revealed by using a method for direct monitoring of D. melanogaster feeding behavior. This demonstrates that dietary restriction elicits robust compensatory changes in food consumption. As a result, the effect of medium dilution is overestimated and, in certain cases, even fully compensated for. Our results strongly indicate that feeding behavior and nutritional composition act concertedly to determine fly lifespan. Feeding behavior thus emerge","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005 Nov","modification":"2025-05-18T11:21:14.967Z","creation":"2025-05-18T11:21:14.967Z"},"accession":"S-EPMC2745347","cross_references":{"pubmed":["16278649"],"doi":["10.1038/nmeth798"]}}