{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["119(10)"],"submitter":["Leuenberger N"],"pubmed_abstract":["As most metabolic studies are conducted in male animals, understanding the sex specificity of the underlying molecular pathways has been broadly neglected; for example, whether PPARs elicit sex-dependent responses has not been determined. Here we show that in mice, PPARalpha has broad female-dependent repressive actions on hepatic genes involved in steroid metabolism and immunity. In male mice, this effect was reproduced by the administration of a synthetic PPARalpha ligand. Using the steroid oxysterol 7alpha-hydroxylase cytochrome P4507b1 (Cyp7b1) gene as a model, we elucidated the molecular mechanism of this sex-specific PPARalpha-dependent repression. Initial sumoylation of the ligand-binding domain of PPARalpha triggered the interaction of PPARalpha with GA-binding protein alpha (GABPa"],"journal":["The Journal of clinical investigation"],"pagination":["3138-48"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2752075"],"repository":["biostudies-literature"],"pubmed_title":["Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice."],"pmcid":["PMC2752075"],"pubmed_authors":["Wahli W","Leuenberger N","Pradervand S"],"additional_accession":[]},"is_claimable":false,"name":"Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice.","description":"As most metabolic studies are conducted in male animals, understanding the sex specificity of the underlying molecular pathways has been broadly neglected; for example, whether PPARs elicit sex-dependent responses has not been determined. Here we show that in mice, PPARalpha has broad female-dependent repressive actions on hepatic genes involved in steroid metabolism and immunity. In male mice, this effect was reproduced by the administration of a synthetic PPARalpha ligand. Using the steroid oxysterol 7alpha-hydroxylase cytochrome P4507b1 (Cyp7b1) gene as a model, we elucidated the molecular mechanism of this sex-specific PPARalpha-dependent repression. Initial sumoylation of the ligand-binding domain of PPARalpha triggered the interaction of PPARalpha with GA-binding protein alpha (GABPa","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Oct","modification":"2026-05-03T18:39:37.22Z","creation":"2019-03-27T00:25:19Z"},"accession":"S-EPMC2752075","cross_references":{"pubmed":["19729835"],"doi":["10.1172/jci39019","10.1172/JCI39019"]}}