biostudies-literatureNandurdikar RSIntramural NIH HHSNCI NIH HHS2760-2https://www.ebi.ac.uk/biostudies/studies/S-EPMC2755573biostudies-literatureUnknown19(10)Here we report a number of novel JS-K structural analogues with sub-micromolar anti-proliferative activities against human leukemia cell lines HL-60 and U937; JS-K is the anti-cancer lead compound O(2)-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate. The ability of these compounds to generate intracellular nitric oxide correlated well with their observed anti-proliferative effects: analogues that had potent inhibitory activity against leukemia cells formed elevated levels of intracellular nitric oxide.Bioorganic & medicinal chemistry lettersSynthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound.PMC2755573N01-CO-2008-00001Z99 CA999999Chakrapani HNandurdikar RSSaavedra JEMaciag AECitro MLShami PJKeefer LKfalseSynthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound.Here we report a number of novel JS-K structural analogues with sub-micromolar anti-proliferative activities against human leukemia cell lines HL-60 and U937; JS-K is the anti-cancer lead compound O(2)-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate. The ability of these compounds to generate intracellular nitric oxide correlated well with their observed anti-proliferative effects: analogues that had potent inhibitory activity against leukemia cells formed elevated levels of intracellular nitric oxide.2009-01-01T00:00:00Z2009 May2024-11-12T07:10:53.739Z2019-03-27T00:25:30ZS-EPMC27555731936465010.1016/j.bmcl.2009.03.115