{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Waldman SA"],"funding":["NCI NIH HHS"],"pagination":["745-52"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2756012"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["301(7)"],"pubmed_abstract":["<h4>Context</h4>The established relationship between lymph node metastasis and prognosis in colorectal cancer suggests that recurrence in 25% of patients with lymph nodes free of tumor cells by histopathology (pN0) reflects the presence of occult metastases. Guanylyl cyclase 2C (GUCY2C) is a marker expressed by colorectal tumors that could reveal occult metastases in lymph nodes and better estimate recurrence risk.<h4>Objective</h4>To examine the association of occult lymph node metastases detected by quantifying GUCY2C messenger RNA, using the reverse transcriptase-polymerase chain reaction, with recurrence and survival in patients with colorectal cancer.<h4>Design, setting, and participants</h4>Prospective study of 257 patients with pN0 colorectal cancer enrolled between March 2002 and J"],"journal":["JAMA"],"pubmed_title":["Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer."],"pmcid":["PMC2756012"],"funding_grant_id":["CA95026","R01 CA095026-01A2","R21 CA112147","CA75123","CA112147","R01 CA075123-02","R01 CA095026","R21 CA112147-01","R01 CA075123","R33 CA112147"],"pubmed_authors":["Li Y","Weinberg DS","Bonaccorso C","Hyslop T","Schulz S","Haaf J","Waldman SA","Barkun A","Nielsen K"],"additional_accession":[]},"is_claimable":false,"name":"Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer.","description":"<h4>Context</h4>The established relationship between lymph node metastasis and prognosis in colorectal cancer suggests that recurrence in 25% of patients with lymph nodes free of tumor cells by histopathology (pN0) reflects the presence of occult metastases. Guanylyl cyclase 2C (GUCY2C) is a marker expressed by colorectal tumors that could reveal occult metastases in lymph nodes and better estimate recurrence risk.<h4>Objective</h4>To examine the association of occult lymph node metastases detected by quantifying GUCY2C messenger RNA, using the reverse transcriptase-polymerase chain reaction, with recurrence and survival in patients with colorectal cancer.<h4>Design, setting, and participants</h4>Prospective study of 257 patients with pN0 colorectal cancer enrolled between March 2002 and J","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Feb","modification":"2025-04-03T23:34:09.815Z","creation":"2019-03-27T00:25:32Z"},"accession":"S-EPMC2756012","cross_references":{"pubmed":["19224751"],"doi":["10.1001/jama.2009.141"]}}