biostudies-literatureBonnefond AMedical Research Council2687-97https://www.ebi.ac.uk/biostudies/studies/S-EPMC2768183biostudies-literatureUnknown58(11)<h4>Objective</h4>A1C is widely considered the gold standard for monitoring effective blood glucose levels. Recently, a genome-wide association study reported an association between A1C and rs7072268 within HK1 (encoding hexokinase 1), which catalyzes the first step of glycolysis. HK1 deficiency in erythrocytes (red blood cells [RBCs]) causes severe nonspherocytic hemolytic anemia in both humans and mice.<h4>Research design and methods</h4>The contribution of rs7072268 to A1C and the RBC-related traits was assessed in 6,953 nondiabetic European participants. We additionally analyzed the association with hematologic traits in 5,229 nondiabetic European individuals (in whom A1C was not measured) and 1,924 diabetic patients. Glucose control-related markers other than A1C were analyzed in 18,6DiabetesGenetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits.PMC2768183G0801056BG0801056G0600331Bouatia-Naji NWiesner SCzernichow SElliott PHercberg SBonnefond ALabrune YBalkau BChevre JCCharpentier GGallois YMarre MLecoeur CRiveline JPPedersen OSladek RHorber FMeyre DJarvelin MRLevy-Marchal CVaxillaire MKaakinen MCauchi STichet JFroguel PHadjadj SDina CfalseGenetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits.<h4>Objective</h4>A1C is widely considered the gold standard for monitoring effective blood glucose levels. Recently, a genome-wide association study reported an association between A1C and rs7072268 within HK1 (encoding hexokinase 1), which catalyzes the first step of glycolysis. HK1 deficiency in erythrocytes (red blood cells [RBCs]) causes severe nonspherocytic hemolytic anemia in both humans and mice.<h4>Research design and methods</h4>The contribution of rs7072268 to A1C and the RBC-related traits was assessed in 6,953 nondiabetic European participants. We additionally analyzed the association with hematologic traits in 5,229 nondiabetic European individuals (in whom A1C was not measured) and 1,924 diabetic patients. Glucose control-related markers other than A1C were analyzed in 18,62009-01-01T00:00:00Z2009 Nov2026-04-13T21:19:20.287Z2026-04-07T13:35:53.955ZS-EPMC27681831965181310.2337/db09-0652