{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Morgan MA"],"funding":["Wellcome Trust"],"pagination":["5813-27"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2772737"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(21)"],"pubmed_abstract":["The zinc-finger PR domain transcriptional repressor Blimp-1/Prdm1 plays essential roles in primordial germ cell specification, placental, heart, and forelimb development, plasma cell differentiation, and T-cell homeostasis. The present experiments demonstrate that the mouse Prdm1 gene has three alternative promoter regions. All three alternative first exons splice directly to exon 3, containing the translational start codon. To examine possible cell-type-specific functional activities in vivo, we generated targeted deletions that selectively eliminate two of these transcriptional start sites. Remarkably, mice lacking the previously described first exon develop normally and are fertile. However, this region contains NF-kappaB binding sites, and as shown here, NF-kappaB signaling is required"],"journal":["Molecular and cellular biology"],"pubmed_title":["Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation."],"pmcid":["PMC2772737"],"funding_grant_id":["059312"],"pubmed_authors":["Arnold SJ","Magnusdottir E","Kuo TC","Tunyaplin C","Calame K","Robertson EJ","Morgan MA","Bikoff EK","Harper J"],"additional_accession":[]},"is_claimable":false,"name":"Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation.","description":"The zinc-finger PR domain transcriptional repressor Blimp-1/Prdm1 plays essential roles in primordial germ cell specification, placental, heart, and forelimb development, plasma cell differentiation, and T-cell homeostasis. The present experiments demonstrate that the mouse Prdm1 gene has three alternative promoter regions. All three alternative first exons splice directly to exon 3, containing the translational start codon. To examine possible cell-type-specific functional activities in vivo, we generated targeted deletions that selectively eliminate two of these transcriptional start sites. Remarkably, mice lacking the previously described first exon develop normally and are fertile. However, this region contains NF-kappaB binding sites, and as shown here, NF-kappaB signaling is required","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Nov","modification":"2025-04-04T07:42:33.68Z","creation":"2019-03-27T00:26:21Z"},"accession":"S-EPMC2772737","cross_references":{"pubmed":["19737919"],"doi":["10.1128/mcb.00670-09","10.1128/MCB.00670-09"]}}