{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Queiroz R"],"pubmed_abstract":["<h4>Background</h4>Trypanosome gene expression is regulated almost exclusively at the post-transcriptional level, with mRNA degradation playing a decisive role. When trypanosomes are transferred from the blood of a mammal to the midgut of a Tsetse fly, they transform to procyclic forms: gene expression is reprogrammed, changing the cell surface and switching the mode of energy metabolism. Within the blood, trypanosomes can pre-adapt for Tsetse transmission, becoming growth-arrested stumpy forms. We describe here the transitions in gene expression that occur during differentiation of in-vitro cultured bloodstream forms to procyclic forms.<h4>Results</h4>Some mRNAs showed changes within 30 min of cis-aconitate addition, whereas others responded 12-24 hours later. For the first 12 h after add"],"journal":["BMC genomics"],"pagination":["495"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2772864"],"repository":["biostudies-literature"],"pubmed_title":["Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons."],"pmcid":["PMC2772864"],"pubmed_authors":["Benz C","Clayton C","Fellenberg K","Queiroz R","Hoheisel JD"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons.","description":"<h4>Background</h4>Trypanosome gene expression is regulated almost exclusively at the post-transcriptional level, with mRNA degradation playing a decisive role. When trypanosomes are transferred from the blood of a mammal to the midgut of a Tsetse fly, they transform to procyclic forms: gene expression is reprogrammed, changing the cell surface and switching the mode of energy metabolism. Within the blood, trypanosomes can pre-adapt for Tsetse transmission, becoming growth-arrested stumpy forms. We describe here the transitions in gene expression that occur during differentiation of in-vitro cultured bloodstream forms to procyclic forms.<h4>Results</h4>Some mRNAs showed changes within 30 min of cis-aconitate addition, whereas others responded 12-24 hours later. For the first 12 h after add","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Oct","modification":"2026-04-18T13:36:05.478Z","creation":"2026-04-07T14:41:14.771Z"},"accession":"S-EPMC2772864","cross_references":{"pubmed":["19857263"],"doi":["10.1186/1471-2164-10-495"]}}